Important Flashcards
what does ach act on when released from pre ganglionic
nicotinic receptors on post ganglionic
what does ach act on when released from post ganglionic
mucsarinic and nicotinic recpeotrs on target organs
what type of receptors are nicotinic
ligand gted ion channels
what type of receptors are muscarinic
gpcrs
action of nicotinic receptors
let sodium in and potassium out for depolarisation
where are a1 mostly located
walls of blood vessels
wwhere are a2 mostly located
presynaptic neurone
what do postganglionic neurones release
norepeniphrene; noradrenaline and epinephrine; adrenaline
high dose of propanolol side effect
bronchospasm
does an antagonist reduce the concentration of active drug
yes
does an antagonist direcetly involve a receptor
no
potency
amount of drug needed to proudce a biological resopnse of magnitude
efficacy
drugs capacity to elicit an effect
are ach nicotninc receptors selective
no
how mnay subunits are in the nicotinic receptors
5
HILL equarion
relationship between ahonist concenrtation and tissue response
first step of two state model
affinity
second step of two state model
efficacy
disadvantage of oral drug
first pass metabolism
action of glucuronic acid on a drug
usually an inactivation of the drug
do basic drugs become more ionised in basic solution
yes
do acidic drugs becoem more ionised in acidic solution
yes
how to double steady state
maintain infusion but double loading dose
potency
amount of medication to elicit an affect
efficacy
max effect
how is potency shown on graph
closer to left
what does potency depend on
ed50; half efficacy
pka
concentration at which the charged an uncharged molecules equal each other
