DRug movement Flashcards
passive diffusion
directly through lipid or through aqueous pores formed by aquaporins that transverse the lipid bilayer
what does the plasma membrane sperate
extracelullar compoartment form intracellular
facilitated
via specilaised carrier proteins that bind the drug on one side of the bind molecule and one side of the membrane
active transport
via specialised carrier proteins
requires energy and can move agaisnt concentration gradients
endocytosis
invagination of a part of the membrane
drug is encased in a small vesicle then released inside the cell
does facilitated diffusion require energy
no
what is an example of endocytosis
vitamin b12
pka
ph at which 50% of the drug is ionised and 50% isnt
henderson hasselbach quation
used to determine proportion of ionised and unionised drugs in a given ph environment
what happens to acidic drugs in an acid environment
become less ionised
what happens to basic drugs in an ionised environment
become less basic
where doe weak bases accumulate
in low ph
where do weak acids accumulate
high ph
where do most oral route drug absoprtions occur and why
small intestine due to large surface area
apparent volume of distribution
extent to which a drug partitions between plasma and tissue compartments
vd= dose/ drug in plasma
