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HMB202 > Immuology > Flashcards

Immuology Flashcards

1
Q

What bond do lysozymes cleave

A

beta 1, 4 glycosidic bond

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2
Q

What are the 4 organs/tissues of the lymphoid system

A

lymph node, thymus, spleen, diffuse lymphoid tissue

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3
Q

What are the 3 lymphatic tissues

A

MALT, GALT, BALT

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4
Q

What is the purpose of primary lymphoid organs

A

development and maturation of lymphocytes

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5
Q

Where do T and B cells mature

A

Thymus, fetal liver & bone marrow

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6
Q

What is similar and different between spleen and lymph node

A

Both filter blood and remove antigens, spleen random while lymph node organized

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7
Q

What do the cortex paracortex, medulla of the lymph node contain

A

cortex - B cells, macrophages, epithelial reticular cells

paracortex - T cells

medulla - plasma cells

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8
Q

What is the red and white pulp of the spleen

A

red - sinusoids

white - WBC, lymphocytes

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9
Q

What is septa (trabeculae)

A

connective tissue that separates lobes into lobules of thymus

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10
Q

What are the 2 main components of the thymus

A

parenchyma (cellular), stroma (connective)

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11
Q

What is the role of ERC 1, 2, and 3

A

ERC1: forms blood-thymus barrier

ERC2: mid-cortex, desmosome junctions

ERC3: deep in cortex, contains T cells

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12
Q

Which ERC educate T cells

A

ERC2 and 3

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13
Q

What is positive selection

A

double negative T cells undergo beta selection to express CD4 and CD8

strong binding to MHC are selected

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14
Q

What is negative selection

A

Single positive T cells that bind too strong to MHC + antigens undergo apoptosis

Those that bind weakly become effectors

Those that bind intermediate become regulatory cells

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15
Q

What do mast cells and neutrophils/macrophages/DCs do

A

release bioactive chemicals, signals other cells and phagocytose pathogens

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16
Q

What are 4 major PRRs

A

membrane bound C-type lectin, toll like receptors

cytosolic NOD like, RIG1-like receptors

17
Q

What is main role of IgM, IgG, IgA, IgE, and IgD

A

stops infections, protects newborns, mucosal defense, allergy, trigger B cells

18
Q

Where is MHC class I and II found and where does the peptide come from

A

MHC class I: all cells attract CD8 antigen made by cell

MHC class II: DC, macrophage attract CD4 foreign antigen

19
Q

What do Th1 and Th2 do

A

secrete interleukins to stimulate macrophages CTL and NK, and stimulate B cells

20
Q

What is Type I hypersensitivity

A

IgE dimers bound to mast cells recognize antigen and degranulates

21
Q

What is Type IV delayed hypersensitivity

A

TH1 cells increase and are activated during first exposure and react and release excess inflammatory cytokines second time

HMB202 (7 decks)

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