Immunotoxicology Flashcards
Too activeimmuneresponsesleadto?
- Enhancement
- Hypersensitivity
- Autoimmunity
Toolittleimmuneresponsesresultsin?
- Immunesuppression
- Infections
- Cancer
The immune system functions as what?
Immune surveillance system (located in thymus, bone marrow, blood etc.)
What can happen to the immune system?
Be suppressed by xenobiotics: immune suppression
Be stimulated to produce autoimmune disease
What is the origin of the immune system?
The stem cell
Three classifications of the immune system: lymphoid tissue
Primary, Secondary, Tertiary
Where do all immune cells initially develop?
Bone marrow
HSC differentiates into what 2 main progenitors from which all other cells develop?
CMP (common myeloid progenitor)
CLP (common lymphoid progenitor)
Two basic types of immunity?
- Innate; 1st line of defense, no specificity of response
- Acquired; 2nd line of defense, yes specificity of response
Memory effects of Innate vs Acquired immunity?
Enhanced response from a repeated exposure or challenge:
Innate - No
Acquired - Yes
What is the immune system?
Complex cellular and physiologic factors to recognize and interact with xenobiotics
Antigen recognition: Antigen processing?
Required to illicit an acquired immune response
Antigen recognition: Antigen-specific receptors?
Initiation of innate immunity
Antigen recognition: Complement?
Destruction of membranes of xenobiotics
What are immunoglobins?
Antibodies important in immunology and the bodies response to challenges from xenobiotics
