Immunosuppressants/Immunomodulators

Question 1

Drugs that are non-selective COX1/2 inhibitors

Answer 1

Aspirin; Naproxen, Ibuprofen, Nabumetone, Indothemacin, Ketorolac

Question 2

Drugs that are COX-2 selective Inhibitors

Answer 2

Celecoxib, Rofecoxib

Question 3

5-Lioxygenase Inhibitors

Answer 3

Zileuton

Question 4

Leukotriene Receptor Antagonists

Answer 4

Montelukast, Zafirlukast

Question 5

Transcriptional activators of Lipocortin

Answer 5

(weakest) Hydrocortisone, Prednisone, Methylprednisolone, Dexamethasone (strongest)

Question 6

Calcinuerin Inhibitors

Answer 6

Cyclosporin, Tacrolimus

Question 7

Transcriptional inhibitors of cytokine production

Answer 7

Calcinuerin inhibitors, corticosteroids, jak/stat inhibitors

Question 8

JAK/STAT Inhibitor example

Answer 8

Tofacitinib

Question 9

Cytokinase antibodies (binds directly to TNF antibody)

Answer 9

Adalimumab; Infliximab; Etanercept (artifical)

Question 10

Cytokine antibodies (Binds directly to IL-5)

Answer 10

Mepolizumab

Question 11

Cytokine antibodies (Binds directly to IL-6)

Answer 11

Toclizumab

Question 12

DNA Synthesis inhibitors classes for leukocyte proliferation

Answer 12

Purine Synthesis inhibitors, Folate synthesis inhibs, rUMP synthesis

Question 13

Types of Purine synthesis inhibitors

Answer 13

Azathioprine, Mycophenolate

Question 14

Types of Folate synthesis inhibitors

Answer 14

Methotrexate

Question 15

Types of rUMP synthesis inhibitors

Answer 15

Leflunomide

Question 16

mTOR inhibitors

Answer 16

Sirolimus

Question 17

Cytokine receptor antibodies (binds to the CD20 receptor)

Answer 17

Rituximab

Question 18

Cytokine receptor antibodies (binds to IgE on Bcell)

Answer 18

Omalizumab

Question 19

Cytokine receptor antibodies (Binds to eosinophils)

Answer 19

Benralizumab

Question 20

Cytokine receptor antibodies (Binds to IL-2 receptor of T-cell)

Answer 20

Basiliximab

Question 21

Cytokine receptors antibodies (Binds to IL-1 receptor)

Answer 21

Anakinra

Question 22

Mechanism of mTOR Inhibitors

Answer 22

In T-cells, Sirolimus +FKBP inhibits mTOR in the cell inhibiting proliferation of genes

Question 23

Mechanism of azathiorpine

Answer 23

2 mechanisms: It can be converted to meTIMP, a direct inhibitor of purine synthesis by binding one of the enzymes needed for purines(Primary therapeutic effect). Or it can also be converted to a derivative of GTP, which would kill the daughter T-cell if taken into the DNA.

Question 24

Mechanism of methotrexate synthesis inhibitors

Answer 24

Inhibits DHFR

Question 25

Mechanism of JAK/STAT Inhibs

Answer 25

Prevents association of JAK and STAT, which is part of the intracellular signalling process when IL-2 binds to the outside receptor.

Question 26

Mechanism of Calcineurin inhibitors

Answer 26

Inhibits the signalling intermedium calcinuerin, which helps transmit signals to the nucleus which would have otherwise produced IL-2.

Question 27

Mechanism of Mycophenolate

Answer 27

Inhibits Inosine monophosphate dehydrogenase, which is an enzyme used in production of GTP