Histology Lab 1 Flashcards
What are the different kinds of aganulocytes?
Monocytes, T-lymphocytes, and B-lymphocytes
What are the different kind of granulocytes?
Neutrophils, Eosinophils, Basophils
What is the main function of neutrophils?
Phagocytose, kill, and digest bacteria
What is the main function of eosinophils?
Moderate inflammatory reactions (and helminthic infections) by inactivating histamine and leuktriene C
What is the main function of basophils?
Mediate inflammatory responses (allergic reactions) similar in manner to mast cells
How do neutrophils cause destruction within phagocytosed bacteria?
1) Azurophilic granules release hydrolytic enzymes into phagosomes to destroy microorganisms, 2) Reactive O2 compounds superoxide (O2-), hydrogen peroxide (H202), and hypochlorous acid (HOCl) formed within phagosomes (catalyzed by myeloperoxidase, MPO) destroy microrganisms
What are the typical life spans of the granulocytes?
1) Neutrophil: 6 hrs to a few days. 2) Eosinophil: 8-12 days but circulate for 4-5 hours. 3) Basophils: A few hrs to a few days
What are the steps in erythrocyte formation?
1) Proerythroblast. 2) Basophilic Erythroblast. 3) Polychromatophilic erythroblast (normoblast). 4) Orthochromatophilic erythroblast. 5) reticulocyte
Which phase of erythrocyte formation is no longer able to under go mitosis? And perhaps give a reason as to why it can’t?
Orthochromatophilic erythroblast; perhaps because nucleus has condensed more and there is further cytoplasm. Nucleus is ready to get expelled from cell
What are the steps in granulocyte (neutrophilic) formation?
1) Myeloblast. 2) Promyelocyte. 3) Neutrophilic Myelocyte 4) Neutrophilic metamyelocyte. 5) Neutrophilic stab cell
What is the first and second most common leukocyte?
Neutrophil (60-70%); Lymphocyte (20%
