Immunosuppressants Flashcards
Ipilimumab
“Ab against CTLA4 –> ↑T cell response
Tx for melanoma”
CALL MUM –> IpiliMUMab CtALL4
Pembrolizumab
“Ab against PD-1 –> ↑T cell response
Tx for melanoma”
Corticosteroids
“Inhibits phospholipase A2 –> ↓prostaglandins
↓ endothelial adhesion molecules –> ↓ phagocytosis, ↑neutrophil counts
Sequestration of lmphocytes in lymphoid tissue”
Azathioprine
Metabolised to 6-mercaptopurine –> interferes with DNA synthesis
Mycophenoalate mofetil
Blocks de novo Guanosine nucleotide synthesis
S/E: PML (infection with JC virus)”
Calcineurin inhibitors
“Example: Ciclosporin, Tacrolimus
MOA: ↓Calcineurin –> ↓T cell activation
Useful in Transplant, Psoriasis, SLE”
JAK inhibitors
“Example: Tofacitinib
MOA: Interferes with JAK-STAT cytokine signalling –> ↓Cytokine production
Useful for Rheumatoid arthritis”
PDE4 inhibitors
“Example: Apremilast
MOA: Inhibition of PDE4 –> ↑cAMP –> ↓Cytokine production
Useful for Psoriasis”
Peddy Premi (PD4E inhibitor, Apremilast)
Anti-thymocyte globulin
“MOA: Thymocytes injected into rabbit, then extract antibodies –> inject into human –> immunosupression on T cells
Useful for Transplantation”
Basiliximab
“MOA: Anti-CD25 antibody –> ↓T cell proliferation
Useful for Transplantation”
“25 leaves of basil”
Abatacept
“MOA: CTLA4-Ig fusion protein against CD80 and CD86 –> ↓T cell activation
Useful for Rheumatoid arthritis”
Natalizumab
“MOA: Antibody against α4 integrin –> ↓transmigration of WBC
Useful for MS”
“Nαtαlizumab”
Tocilizumab
“MOA: Anti-IL-6 receptor antibody –> ↓Macrophage, T cell, B cell, Neutrophil activation
Useful for Castleman’s disease, Rheumatoid arthritis”
Toc-IL-6-zumab
Anti-TNF-αantibodies
“Example: Infliximab
Useful for RhA, Ank Spond, Psoriasis, IBD”
TNF αantagonists
“Example: Etanercept
MOA: TNF-αreceptor against to IgG Fc –> binds to TNF-α(decoy receptor)
Useful for RhA, Ank Spond, Psoriasis”
