Immunostimulants

Question 1

Filgrastim (Neupogen) - Class & MOA

Answer 1

• Class: Immunostimulants: Colony Stimulating Factors
• MOA: stimulates production, maturation, & activation of neutrophils to reduce incidence of infection

Question 2

Filgrastim (Neupogen) - Indications & Route

Answer 2

• Indications:
  > myelosuppression conditions (antineoplastic drugs, bone marrow transplant, HIV)
• Route : SQ

Question 3

Filgrastim (Neupogen) - AEs & Nursing

Answer 3

• AEs:
  > fatigue
  > bone pain
  > fever
• Nursing:
  > frequent lab monitoring (CBC before treatment & twice weekly) teach self-admin

Question 4

Epoetin-Alfa (Epogen, Procrit) - class & MOA

Answer 4

• Class: Immunostimulants: Colony Stimulating Factors
• MOA: erythropoietin factor controlling rate of RBC production

Question 5

Epoetin-Alfa (Epogen, Procrit) - Indications & Contra

Answer 5

• Indications:
  > treat disorders of RBC formation to dcr need for trasfusions
  > renal failure
  > antineoplastic treatments
• Contraindications
  > angina
  > anticoag therapy
  > caution in CHF

Question 6

Epoetin-Alfa (Epogen, Procrit) - AEs & Nursing

Answer 6

• AEs
  > fatigue
  > bone pain
  > edema
  > HTN
  > headache
  > fever
  > (DVT, CVA, MI have occured w/ treatment)
• Nursing
  > monitor CBC weekly
  > check VS (risk for HTN)
  > anaglesia for bone pain
  > Goal Hgb greater than 10
  > Hold or dose reduction if Hgb > 12