Immunophenotype Unit 2

Question 1

CD20

Answer 1

mature B cells (expressed in chronic leukemia)

Question 2

CD19

Answer 2

on all B cells regardless of maturity

Question 3

CD34

Answer 3

immature cells regardless of lineage

Question 4

TDT

Answer 4

hallmark lymphoblast marker (immature lymphocytes) (helpful for distinguishing lymphoid blast cells because TDT is not present in myeloid blasts)

Question 5

CD3 and CD7

Answer 5

immature T cells

Question 6

CD4

Answer 6

T helper cells

Question 7

CD8

Answer 7

NK T cells

Question 8

CD34 and CD117

Answer 8

expressed in acute myeloblastic leukemia (AML) (immature myeloblasts)

Question 9

surface immunoglobulin

Answer 9

expressed on mature B cells

Question 10

CD5

Answer 10

normally T cell marker, but present on B cells in SLL/CLL and mantle cell lymphoma

Question 11

CD23

Answer 11

present in B cells in CLL/SLL (helps tell apart from mantle cell lymphoma)

Question 12

CD10

Answer 12

germinal center B marker, present in follicular lymphoma and burkitt lymphoma

Question 13

BCL6

Answer 13

surface marker that is present in germinal center B cells

Question 14

BCL2

Answer 14

present in follicular lymphoma due to translocation

Question 15

BCL1 (cyclin D1)

Answer 15

present in mantle cell lymphoma due to translocation

Question 16

MYC

Answer 16

present in burkitt due to translocation

Question 17

CD30

Answer 17

only in reed-sternberg cells

Question 18

CD15

Answer 18

only in reed-sternberg cells

Question 19

MPO & auer rods

Answer 19

MPO forms auer rods. Hallmark of myeloblast.