Immunopharmacology 1

Question 1

Innate Immunity Simply explained

Answer 1

• toll like receptors expressed on sensing cells detect fragments of pathogens
• they release cytokines and chemokines
• chemokines first - attract specific immune cells
• cytokines second - modulate immune cell activation

Question 2

PAMPs

Answer 2

• pathogen associated molecular patterns
• CONSERVED chemical elements with low variance between subclasses of pathogens
• gram+ bacteria: DNA, LP in cell walls
• gram- bacteria: DNA, LPS, flagellin
• our immune recongizes there highly conserved motifs that we don’t make

Question 3

antigens