Antineoplastics Flashcards
1
Q
Historical classification of antineoplastic drugs
A
- DNA adduct generating agents
- antimetabolites
- antibiotics
- natural plant derivatives
- hormones and antagonists
- recombinant agent
2
Q
What agents generate DNA adducts and what is their MOA?
A
- nitrogen mustards, nitrosureas, platinum drugs
- highly reacting chemicals that bind covalently to macromolecules, especially purine and pyrimidine bases of DNA
- they have a CH2-CH2-Cl (chloroethyl group) attached
