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PBD > Immunopathology (chapter 6) > Flashcards

Immunopathology (chapter 6) Flashcards

1
Q

HLA-DR4

A

Rheumatoid arthritis

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2
Q

HLA-DR3/HLA-DR4

A

Type I diabetes

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3
Q

HLA-B27

A

Ankylosing spondylitis and postgonococcal arthritis

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4
Q

HLA-DR3

A

Autoimmune hepatitis and primary Sjögren syndrome

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5
Q

PTPN22

A

Rheumatoid arthritis (protein tyrosine phosphatase)

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6
Q

NOD2

A

Crohn’s disease

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7
Q

Bruton tyrosine kinase

A

X-linked agammaglobulinemia (Bruton disease)

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8
Q

22q11 abnormality

A

DiGeorge syndrome (CATCH22!)

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9
Q

CD40L abnormality (X-linked or autosomal recessive)

A

Hyper-IgM syndrome

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10
Q

WASP mutation

A

Wiskott-Aldrich syndrome (Wiskott-Aldrich syndrome protein)

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11
Q

mast cell mediators of vasodilation

A

HA, PAF, leukotrienes C4/D4/E4, neutral proteases that activate complement and kinins, PgD2

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12
Q

mast cell mediators of smooth muscle spasm

A

leukotrienes C4/D4/E4, HA, PgD2, PAF

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13
Q

mast cell mediators of cellular infiltration

A

cytokines (e.g. cytokines and TNF), leukotriene B4, eosinophil and neutrophil chemotactic factors

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14
Q

mediators of eosinophil function

A

eotaxin, IL-5

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15
Q

hemolytic anemia (antigen)

A

RBC membrane proteins

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16
Q

Goodpasture syndrome (antigen)

A

basement membrane, especially lungs and kidney

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17
Q

Myasthenia gravis (antigen)

A

AChR

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18
Q

Graves disease (antigen)

A

TSHR

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19
Q

Hashimoto’s thyroiditis (antigen)

A

thyroid cells

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20
Q

SLE (antigen)

A

multiple (DNA, nuclear protein)

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21
Q

RA (antigen)

A

connective tissue

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22
Q

insulin-dependent diabetes (antigen)

A

pancreatic islet beta cells

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23
Q

autoimmune thrombocytopneic purpura (antigen)

A

platelet membrane proteins

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24
Q

vasculitis caused by ANCA (antigen)

A

neutrophil granule proteins

25
Q

acute rheumatic fever (antigen)

A

streptococcal cell wall antigen

cross-reacts with myocardial antigen

26
Q

pernicious anemia (antigen)

A

intrinsic factor of gastric parietal cells

27
Q

poststreptococcal glomerulonephritis (antigen)

A

streptococcal cell wall antigens (“implant” in glomerular basement membrane)

28
Q

polyarteritis nodosa (antigen)

A

HBV antigens

29
Q

reactive arthritis (antigen)

A

bacterial antigens

30
Q

serum sickness (antigen)

A

foreign serum protein

31
Q

arthus reaction (antigen)

A

various foreign proteins

32
Q

rheumatoid arthritis (T cell target)

A

citrullinated self proteins

33
Q

MS (T cell target)

A

myelin basic protein

34
Q

type I diabetes (T cell target)

A

pancreatic islet beta cells

35
Q

inflammatory bowel disease (T cell target)

A

enteric bacteria, self antigens

36
Q

psoriasis (T cell target)

A

unknown

37
Q

contact dermatitis (T cell target)

A

various environmental antigens

38
Q

SLE (autoAbs)

A

ANA, anti-dsDNA, anti-Sm

39
Q

drug-induced LE (autoAbs)

A

ANA, anti-histone

40
Q

systemic sclerosis/scleroderma (autoAbs)

A

ANA, anti-Scl-70

41
Q

CREST syndrome (autoAbs)

A

anti-centromere

42
Q

Sjögren syndrome (autoAbs)

A

anti-SS-A (Ro), anti-SS-B (La)

43
Q

autoimmune myositis (autoAbs)

A

anti-Jo-1

44
Q

mixed connective tissue disease (autoAbs)

A

anti-U1-RNP (U1 ribonucleoprotein)

45
Q

C1, C2 (most common), C4 deficiency

A

little to no increase in susceptibility to infections

46
Q

C3 deficiency

A

serious, recurrent pyogenic infections

47
Q

C5, C6, C7, C8, or C9 deficiency

A

recurrent neisserial (gonococcal or meningococcal) infections

48
Q

C1inh deficiency

A

hereditary angioedema

49
Q

X-linked defect in gamma-chain receptors for interleukins

A

SCID

50
Q

autosomal recessive adenosine deaminase (ADA) deficiency

A

SCID

51
Q

ATM gene mutation (autosomal recessive)

A

ataxia telangiectasia

52
Q

AIDS-defining conditions

A 
invasive cervical cancer
HIV-related encephalopathy
Kaposi sarcoma
Burkitt lymphoma
immunoblastic lymphoma
primary lymphoma of brain
wasting syndrome attributed to HIV
53
Q

primary amyloidosis

A

monoclonal plasma cell proliferations; immunoglobulin light chains, chiefly lambda type

54
Q

secondary amyloidosis

A

chronic inflammatory conditions; SAA

55
Q

hemodialysis-associated amyloidosis

A

chronic renal failure; beta2-microglobulin

56
Q

systemic senile amyloidosis

A

transthyretin

57
Q

senile cerebral amyloidosis

A

Alzheimer disease; APP

58
Q

medullary carcinoma of thyroid

A

calcitonin

59
Q

islets of Langerhans

A

type 2 diabetes; islet amyloid peptide

PBD (3 decks)

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