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Immunopathology (chapter 6) Flashcards

1
Q

HLA-DR4

A

Rheumatoid arthritis

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2
Q

HLA-DR3/HLA-DR4

A

Type I diabetes

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3
Q

HLA-B27

A

Ankylosing spondylitis and postgonococcal arthritis

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4
Q

HLA-DR3

A

Autoimmune hepatitis and primary Sjögren syndrome

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5
Q

PTPN22

A

Rheumatoid arthritis (protein tyrosine phosphatase)

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6
Q

NOD2

A

Crohn’s disease

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7
Q

Bruton tyrosine kinase

A

X-linked agammaglobulinemia (Bruton disease)

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8
Q

22q11 abnormality

A

DiGeorge syndrome (CATCH22!)

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9
Q

CD40L abnormality (X-linked or autosomal recessive)

A

Hyper-IgM syndrome

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10
Q

WASP mutation

A

Wiskott-Aldrich syndrome (Wiskott-Aldrich syndrome protein)

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11
Q

mast cell mediators of vasodilation

A

HA, PAF, leukotrienes C4/D4/E4, neutral proteases that activate complement and kinins, PgD2

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12
Q

mast cell mediators of smooth muscle spasm

A

leukotrienes C4/D4/E4, HA, PgD2, PAF

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13
Q

mast cell mediators of cellular infiltration

A

cytokines (e.g. cytokines and TNF), leukotriene B4, eosinophil and neutrophil chemotactic factors

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14
Q

mediators of eosinophil function

A

eotaxin, IL-5

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15
Q

hemolytic anemia (antigen)

A

RBC membrane proteins

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16
Q

Goodpasture syndrome (antigen)

A

basement membrane, especially lungs and kidney

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17
Q

Myasthenia gravis (antigen)

A

AChR

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18
Q

Graves disease (antigen)

A

TSHR

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19
Q

Hashimoto’s thyroiditis (antigen)

A

thyroid cells

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20
Q

SLE (antigen)

A

multiple (DNA, nuclear protein)

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21
Q

RA (antigen)

A

connective tissue

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22
Q

insulin-dependent diabetes (antigen)

A

pancreatic islet beta cells

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23
Q

autoimmune thrombocytopneic purpura (antigen)

A

platelet membrane proteins

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24
Q

vasculitis caused by ANCA (antigen)

A

neutrophil granule proteins

25
acute rheumatic fever (antigen)
streptococcal cell wall antigen | cross-reacts with myocardial antigen
26
pernicious anemia (antigen)
intrinsic factor of gastric parietal cells
27
poststreptococcal glomerulonephritis (antigen)
streptococcal cell wall antigens ("implant" in glomerular basement membrane)
28
polyarteritis nodosa (antigen)
HBV antigens
29
reactive arthritis (antigen)
bacterial antigens
30
serum sickness (antigen)
foreign serum protein
31
arthus reaction (antigen)
various foreign proteins
32
rheumatoid arthritis (T cell target)
citrullinated self proteins
33
MS (T cell target)
myelin basic protein
34
type I diabetes (T cell target)
pancreatic islet beta cells
35
inflammatory bowel disease (T cell target)
enteric bacteria, self antigens
36
psoriasis (T cell target)
unknown
37
contact dermatitis (T cell target)
various environmental antigens
38
SLE (autoAbs)
ANA, anti-dsDNA, anti-Sm
39
drug-induced LE (autoAbs)
ANA, anti-histone
40
systemic sclerosis/scleroderma (autoAbs)
ANA, anti-Scl-70
41
CREST syndrome (autoAbs)
anti-centromere
42
Sjögren syndrome (autoAbs)
anti-SS-A (Ro), anti-SS-B (La)
43
autoimmune myositis (autoAbs)
anti-Jo-1
44
mixed connective tissue disease (autoAbs)
anti-U1-RNP (U1 ribonucleoprotein)
45
C1, C2 (most common), C4 deficiency
little to no increase in susceptibility to infections
46
C3 deficiency
serious, recurrent pyogenic infections
47
C5, C6, C7, C8, or C9 deficiency
recurrent neisserial (gonococcal or meningococcal) infections
48
C1inh deficiency
hereditary angioedema
49
X-linked defect in gamma-chain receptors for interleukins
SCID
50
autosomal recessive adenosine deaminase (ADA) deficiency
SCID
51
ATM gene mutation (autosomal recessive)
ataxia telangiectasia
52
AIDS-defining conditions
``` invasive cervical cancer HIV-related encephalopathy Kaposi sarcoma Burkitt lymphoma immunoblastic lymphoma primary lymphoma of brain wasting syndrome attributed to HIV ```
53
primary amyloidosis
monoclonal plasma cell proliferations; immunoglobulin light chains, chiefly lambda type
54
secondary amyloidosis
chronic inflammatory conditions; SAA
55
hemodialysis-associated amyloidosis
chronic renal failure; beta2-microglobulin
56
systemic senile amyloidosis
transthyretin
57
senile cerebral amyloidosis
Alzheimer disease; APP
58
medullary carcinoma of thyroid
calcitonin
59
islets of Langerhans
type 2 diabetes; islet amyloid peptide

PBD (3 decks)

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