Immunopathology 2 Flashcards
Autoimmunity can arise from these 3 factors?
Genetic
Environmental
Immunity
Name 4 autoimmune disorders:
- SLE
- Rheumatoid arthritis
- Sjogren
- Scleroderma
- Dermatomyositis
SLE damage is caused by what?
mostly due to deposition of immune complexes
what is noticible in this picture?
SLE (Class IV): deposits thickening capillary walls and thrombi (blue arrows)
SLE is what type of hypersensitivity?
Hypersensitivity type 3
what disease is this?
what are the arrows pointing at?
Lupus nephritis (class 4 lupus)
arrows point at wire loop lesions
what disease causes this?
SLE
what is being shown here? (arrows)
what disease causes this?
Libman-Sacks endocarditis of the mitral valve in lupus erythematosus. The vegetations attached to the margin of the thickened valve leaflet are indicated by arrows. Non-bacterial verrucous
SLE causes this
what disease is this?
what is the name for this symptom?
SLE
malar rash
in what disease we see this?
what is being shown here?
SLE class 4
narrowing of glomerular capillaries by mesangial and endocapillary proliferation. Wire-loop deposits and hyaline thrombi are segmentally distributed
what is the cell being shown by the arrow?
This characteristic appearace is found in what body parts or areas?
Pleural fluid. A neutrophil with an ingested large nucleus (nucleophagocytosis) (arrow) compressing the nucleus of the neutrophil (asterisk).
This appearance is characteristic of the L-E cell found in the blood, marrow, or serous effusions in patients with lupus erythematosus
what disease causes this?
Rheumatoid arthritis
In rheumatoid arthritis, what joint is usually spared? In what other disease is this joint not spared?
distal interphalangeal joint (DIP) unlike in osteoarthritis.
what disease causes this?
what is going on in this picture?
Rheumatoid Arthritis
subsynovial tissue containing a dense lymphoid aggregate is seen
what disease is this?
what is being seen in this picture?
Rheumatoid arthritis
Low magnification reveals marked synovial hypertrophy with formation of villi.
what disease causes this?
What is being shown here?
Rheumatoid arthritis
A fibrinoid nodule = fibrinoid necrosis encapsulated by eptitheloid cells (granuloma formed)
what is the clinical feature of rheumatoid arthritis?
- small joints of hands and feet
- early morning stiffness
- anything attached to the wrist will be affected
- ulnar deviation
- flexor tendon tendosynovitis (hallmark)
what is this?
what disease?
swann neck deformity
rheumatoid arthritis
what disease?
what is it?
rheumatoid arthritis
boutonnière deformity
what disease causes this?
what is it?
rheumatoid arthritis
popliteal (Baker) cyst develops posteriorly and inferiorly to the knee as a distention of a local bursa
what are the hematologic findings of rheumatoid arthritis?
Anemia of chronic disease (ACD)
What will be the lab findings of rheumatoid arthritis?
- Rheumatoid Factor (RF): most common is IgM
- Normal to increased serum C3
- C3 levels are low in synovial fluid
- Synovial fluid analysis: presence of white cells
- RF can be detected in synovial fluid
- *antibodies to cyclic citrullinated peptides (anti-CCPs)
what can be expected in radiological labs for rheumatoid arthritis?
Plain X-ray, USG, MRI
what is Sjögren Syndrome?
chronic, slowly progressive autoimmune disease characterized by lymphocytic infiltration of exocrine glands
what are the main symptoms seen in Sjögren Syndrome?
xerostomia dry mouth
dry eyes (keratoconjunctivitis)
dental caries
why do you see decrease in tears and saliva (sicca syndrome)?
lymphocytic infiltrate and fibrosis of lacrimal and salivary gland
what cells are mostly predominate the inflammation?
CD4+ helper T-cells predominate the inflammation, along with B cells, and plasma cells
what other anti-bodies can be found in inflammation during Sjögren Syndrome? which are the most important?
also antinuclear antibodies such as rheumatoid factor , and other are present
most important:
SS-A (Ro)
SS-B (La)
Sjögren Syndrome is associated with what two HLA genes?
HLA association: HLA-B8, HLA-DR3
in Sjögren Syndrome, what do we find in the salivary glands?
periductal and perivascular lymphocytic infiltration
lymphoid follicles with germinal centers may appear
in Sjögren Syndrome, how do the ducts look? what does this lead to later?
ductal lining cells show hyperplasia, this leads to obstruction
later there is acinar atrophy, fibrosis, and hyalinization
where is this?
In what disease can we see this?
what is the left circle?
what is the right circle?
salivary gland
sjogren disease
gland
duct
what can we see in this picture?
in what disease can we expect this?
Note: dense lymphocytic inflammation, fibrosis
Sjogren syndrome
what can we find in the labs for sjogren syndrome?
antibodies in serum: SS-A(Ro), SS-B(La)
positive RF
patients with sjogren syndrome are at risk of what cancer?
lymphoma of marginal zone
what is Systemic Sclerosis (scleroderma)?
chronic inflammation (autoimmune),
2) widespread damage to small blood vessels, and
3) progressive interstitial and perivascular fibrosis in skin (hardening of skin (it stretches)) and multiple organs
in scleroderma, why is there autoimmunity?
CD4+ T cells responding to unknown antigen in skin
this activates inflammatory cells and fibroblasts
cytokines from T-cells (TGF-β, IL-13)