Immunopatholgy II (Autoimmune diseases)

Question 1

Expression of the MHC D locus gene or polymorphism in the PTPN-22 gene are frequently related to what?

Answer 1

Autoimmunity.

Question 2

What is the incidence of systemic lupid erythematous?

Answer 2

1/700

Question 3

Antinuclear antibody/antigen complexes are a hallmark of what disorder?

Answer 3

Hallmark of the Systemic lupus eryhtemetous.

Question 4

A homogenous staining patern indicates antibody binding to what?

Answer 4

Chromatin
Ds-DNA
Histones
Typically related to RA and SLE

Question 5

Rim staining patterns indicate Ab binding to what?

Answer 5

ds-DNA

indicitive of SLE

Question 6

Speckled staining indicates Ab binding to what?

Answer 6

Histones
Ribonucleoproteins
indicitive of SLE and Sjorgens syndrome.

Question 7

Centromere staining patterns bind ab to what?

Answer 7

Bind to centromeres and are a sign of CREST

Question 8

Nucleolar staining patterns bind Ab to what?

Answer 8

Bind ab to nucleolar RNA indicitative of SLE and PSS.

Question 9

Antinuclear antibodies to dsDNA is related to what disorder?

Answer 9

Systemic lupus Erythematous

Question 10

Antinuclear antibodies to Antihistone is related to what disorder?

Answer 10

Drug induced LE and SLE

Question 11

Anti SM antinuclear antibodies are related to what disorder?

Answer 11

SLE

Question 12

Nuclear RNP is related to what disorder?

Answer 12

SLE

Question 13

SS-A (ro) and SS-B (LA) are related to what disorder?

Answer 13

Sjorgen Syndrome.

Question 14

Scl-70 is related to what disorder?

Answer 14

Systemic sclerosis

Question 15

Anticentromere is related to what disorder?

Answer 15

CREST

Question 16

Antismith ANAs bind what specifically?

Answer 16

Ribonucleoprotein

Question 17

What causes lupus driven acute fibrinoid necrosis of the vasculature?

Answer 17

A type III inflammatory reaction in which circulating immune complexes lodge in the vascular beds activating compliment.

Question 18

Onion skin lesions around vasculature are a classical symptom of what?

Answer 18

Proliferative vascular lesions caused by Lupus fibrosis.

Question 19

What are the two types of glomerular nephritis caused by lupus that we need to know?

Answer 19

Membranous glomerulonephritis and

Diffuse proliferative glomerulonephritis.

Question 20

What is the primary difference between acute serositis and chronic serositis?

Answer 20

Acute serositis is due to exudation of fibrin.

Chronic serositis is due to proliferation of fibrous tissue leading to thickened membranes and adhesions.

Question 21

Libman-Sacks endocarditis caused by lupus is unique in that it….

Answer 21

Small medium sized vegetations that occur on iether/both sides of the heart valve leaflets.

Question 22

What percentage of lupus patients will present with pleuritis with effusion?

Answer 22

50% of cases

Question 23

What type of damage is seen in lupus of the CNS?

Answer 23

Small vessel thickening by intimal porliferation leading to ischemia and microinfarcts.

Question 24

What percentage of lupus patients will have a 5 year survival?

Answer 24

90%

Question 25

What percentage of lupus patients will have a 10 year survival rate?

Answer 25

80%

Question 26

What is Chronic discoid LE?

What lab tests will it be positive for?

Answer 26

Variety of skin lesions

Tests positive for ANAs, Anti-dsDNA.

Question 27

What is subacute cutaneous LE?

Answer 27

Diffuse superficial nonscarring, photosensitive lesions related to lupus

Question 28

D-penicillamine, procainamide, hydralzine, and isoniazid are all known to possiby cause what?

Answer 28

Drug induced lupus

Capable of going into remission.