Immunomodulator (general and specific other than adv effect and MOA)

Question 1

What is the net result of administration of cyclosporine and tacrolimus???

Answer 1

Inhibition of transcription of IL-2 gene

Question 2

Which binds to FK-506 and which binds to cyclophilin???

Answer 2

Tacrolimus(binds to FK-506) and Cyclosporine(binds to cyclophilin)

Question 3

Which side effect are common with tacrolimus than with cyclosporine???

Answer 3

Hyperglycemia and neurotoxicity

Question 4

Which side effect (bouncers!!!) are not caused by tacrolimus???

Answer 4

Hirsutism, Gum hyperplasia, Hyperuricemia Hyperlipidemia…. Remember that these are the side effect of cyclosporine

Question 5

What are the uses of methotrexate???

Answer 5

PROGRAM on WTC

Psoriasis(topically), Rheumatoid arthritis, Osteosarcoma, GVHD, Rheumatoid arthritis, ALL, Multiple sclerosis, Wegener’s granulomatosis, Trophoblastic Disease, Crohn’s disease are the Causes.

Question 6

What does PROGRM on WTC stands for???

Answer 6

These stands for the uses of methotrexate.

Psoriasis(topically), Rheumatoid arthritis, Osteosarcoma, GVHD, Rheumatoid arthritis, ALL, Multiple sclerosis, Wegener’s granulomatosis, Trophoblastic Disease, Crohn’s disease are the Causes.

Question 7

What are the uses of hydroxyurea???

Answer 7

PACE

PCV
Anaemia(sickle cell anaemia)
CML
Essential thrombocytosis

Question 8

What does PACE stands for???

Answer 8

Uses of hydroxyurea

PCV
Anaemia(sickle cell anaemia)
CML
Essential thrombocytosis