Adverse effect- mixed part 1

Question 1

PPI causes hypothyroidism or hyperthyroidism as long term side effect????

Answer 1

It does not cause both.

Question 2

Enterocutaneous fistula closure is seen with which drug`

Answer 2

Infliximab

Question 3

What are the side effect of isotretinoin??

Answer 3

Hyperlipidemia , myalgia, arthralgia

Question 4

Which causes greater haemorrhagic cystitis

Answer 4

Ifosfamide is greater to cyclophosphamide

Question 5

Drugs causing raynaud’s disease

Answer 5

Blood Cannot Pass in Narrow Blood VesselsBleomycin, Cisplatin ,Ponatinib, Nilotinib, Vinblastine

Question 6

What are the side effect of L Asparaginase

Answer 6

5H are the side effect HyperglycemiaHyperlipidemia induced pancreatitisHypersensitivity HepatotoxicityHemorrhage or thrombosis

Question 7

What is the most common cause of SIADH

Answer 7

The most common cause is Vincristine. Cyclophosphamide can also cause SIADH

Question 8

What are the causes of Hand and foot syndrome

Answer 8

Capecitabine , 5FU Doxorubicin GemcitabineSunitinib, Sorafenib and Pazopanib

Question 9

Between 5FU and capecitabine which causes maximum Hand and foot syndrome

Answer 9

Ans is Bouncer!!! Capecitabine.

Question 10

What are the drug causing cardiotoxicity

Answer 10

FAT Cardio 5FUAnthracyclines (Maximum with doxorubicin and daunorubicin)TrastuzumabCyclophosphamide at high doses.

Question 11

How does 5FU causes cardiotoxicity???

Answer 11

It causes coronary vasospasm and precipitates ischemia.

Question 12

Radiation recall syndrome

Answer 12

Dactinomycin Doxorubicin Daunorubicin

Question 13

What are the side effect of chloroquine

Answer 13

BCG LQ Bull eye retinopathyConvulsionG6PD deficient haemolysisLow ocular pressure in eyeQR and T wave abnormality

Question 14

What does BCG LQ stands for???

Answer 14

These are the side effect of chloroquine. Bull eye retinopathyConvulsionG6PD deficient haemolysisLow ocular pressure in eyeQR and T wave abnormality

Question 15

Side effect of Ethionamide

Answer 15

ETHIONElevated ALT/ASTTaste changeHypothyroidismImpotenceOcular toxicity Nausea and Vomiting

Question 16

Side effect of sulphonamides

Answer 16

BIKASH Bone marrow suppression Insoluble in urine crystalluriaKernicterus in newbornAIPAgranulocytosisSJS or would be given as Rash Haemoglobin (which is Met)

Question 17

Out of sulphonamides side effect mnemonic BIKASH how many are reasoning and how many are direct???

Answer 17

Only 2 is reasoning and 4 are direct. Bone marrow suppression Insoluble in urine crystalluriaKernicterus in newbornAIPAgranulocytosisSJS or would be given as Rash Haemoglobin (which is Met)

Question 18

SJS side effect of sulfonamide can also be mentioned as???

Answer 18

Rash The other side effect include BIKASH Bone marrow suppression Insoluble in urine crystalluriaKernicterus in newbornAIPAgranulocytosisSJS or would be given as Rash Haemoglobin (which is Met)

Question 19

Which antitubercular drug causes hepatotoxicity and which cause nephrotoxicity???

Answer 19

HRZ causes hepatotoxicity and E causes nephrotoxicity

Question 20

HRZ causes hepatotoxicity. Can you grade it???

Answer 20

Z>H>R Pyrazinamide> Isoniazid> Rifampicin

Question 21

Which ATT crosses the BBB(maximum amount) and is associated with neuropsychiatric symptoms like memory loss , euphoria dnd hallucination as seen in psychosis

Answer 21

Isoniazid

Question 22

Isoniazid is associated with which neurological adverse effect???

Answer 22

Associated with neuropsychiatric symptoms like memory loss , euphoria dnd hallucination as seen in psychosisMaximum crosses the BBB.

Question 23

Maximum and minimum peripheral neuropathy is caused by which NRTI drug???

Answer 23

Stavudine (maximum peripheral neuropathy) and Lamivudine (minimum peripheral neuropathy)

Question 24

What is the order of hemolysis in G6PD deficiency with antimalarials drug

Answer 24

Primaquine > Chloroquine > Quinine

Question 25

Which causes flaccid paralysis and which cause spastic paralysis in helminthes

Answer 25

Ivermectin piperazine ( flaccid paralysis )Praziquantel metrifonate pyrantel pamoate ( spastic paralysis )

Question 26

Which causes more photosensitivity??? Demeclocycline or Doxycycline

Answer 26

Demeclocycline

Question 27

Which the fluoroquinolones with maximum photosensitivity and QT prolongation???

Answer 27

Sparfloxacin