Immunology Post-Midterm

Question 1

HLA RA

Answer 1

HLA-DR-1,4

Question 2

HLA MS

Answer 2

HLA-DR-2

Question 3

HLA SLE

Answer 3

HLA-DR-2,3

Question 4

Pathology RA

Answer 4

Type 3, 4 Hypersensitivity
Ab: Rheumatoid factor Ab
Inflammation (T1 cytokines)
TNF, IL-1, IL-17

Question 5

Pathology MS

Answer 5

Type 4 hypersensitivity
Destruction of CNS myelin
Ab: Myelin basic protein Ab
++ Mononuclear phagocytes

Question 6

Pathology SLE

Answer 6

Type 3 hypersensitivity
Ab to soluble Ag
Nuclear antigens

Question 7

Features RA

Answer 7

Aching, swollen joints

Question 8

Features MS

Answer 8

Tingling, numbness, loss of balance

Question 9

Features SLE

Answer 9

Photosensitivity, facial rash, spontaneous abortion; Immune complexes trapped in kidney, skin, joints

Question 10

Treatment RA

Answer 10

CTLA-4-Ig (CD152-Ig) Abatacept

TNFR-Ig Enbrel/Etanercept

Question 11

Treatment MS

Answer 11

Anti-VLA-4 Ab (Anti-CD49d Ab) Natalizumab
Anti-IL2R Ab (Anti-CD25 Ab) Daclizumab
Anti-p40 Ab Briakinumab

Question 12

Treatment SLE

Answer 12

Anti-CD20 Ab Rituximab

Anti-BLys Ab (IgG1 MAb) Benlysta

Question 13

Investigation RA

Answer 13

Rheumatoid factor

Question 14

Investigation MS

Answer 14

MRI

Question 15

Investigation SLE

Answer 15

Anti-ds-DNA Ab
Anti-cardiolipin Ab
C3, C4

Question 16

Psoriasis (though not a required condition) can be treated with…

Answer 16

Anti-p40 Ab (Briakinumab)