Immunology Mechanism

Question 1

Leukine

Answer 1

GM-CSF–> increases neutrophil and monocytes and improves function.

Question 2

Neupogen

Answer 2

G-CSF–> increase neutrophils

Question 3

Neulasta

Answer 3

G-CSF–> increase neutrophils

Question 4

Epogen

Answer 4

ESA —> stimulates BFU +CFU to promote erythropoiesis

Question 5

Procrit

Answer 5

ESA —> stimulates BFU +CFU to promote erythropoiesis

Question 6

Aranesp

Answer 6

ESA —> stimulates BFU +CFU to promote erythropoiesis

Question 7

Pegasys

Answer 7

Recombinant interferon,
Induce innate response
inhibit viral replication
suppress cell cycle/proliferation
induce apoptosis
induce anti-angiogenesis.

Question 8

Pegintron

Answer 8

Recombinant interferon,
Induce innate response
inhibit viral replication
suppress cell cycle/proliferation
induce apoptosis
induce anti-angiogenesis.

Question 9

Reopro

Answer 9

Chimeric IgG against GIIb/IIIa

Question 10

Orthoclone

Answer 10

murine IgG against CD3

Question 11

Mabthera

Answer 11

chimeric IgG against CD20

Question 12

Zenapax

Answer 12

Humanized IgG against CD25 [IL-2R]

Question 13

Simulect

Answer 13

Chimeric IgG against CD25 [IL-2R]

Question 14

Campath

Answer 14

Humanized IgG against CD52.

Question 15

Rhogam

Answer 15

Exogenous Rho-Ig from human serum to prevent sensitization of mother to Rho-positive erythrocytes.