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Immunology > Drug Interaction > Flashcards

Drug Interaction Flashcards

1
Q

Calcium Channel Blockers

A

CYP3A4 Inhibitor

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2
Q

Antifungals (azoles)

A

CYP3A4 Inhibitors

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3
Q

Clarithromycin, Erythromycin
CYP EFFECT

A

CYP3A4 Inhibitor

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4
Q

Protease Inhibitors

A

CYP3A4 Inhibitor

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5
Q

Gastric Acid Suppressors

A

CYP3A4 Inhibitor

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6
Q

Grape Fruit Juice

A

CYP3A4 Inhibitor

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7
Q

Naficillin

A

CYP3A4 Inducers

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8
Q

Rifampin

A

CYP3A4 Inducers

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9
Q

Caspofungin

A

CYP3A4 Inducers

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10
Q

Anticonvulsants

A

CYP3A4 Inducers

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11
Q

Terbenafine

A

CYP3A4 Inducers

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12
Q

Octreotide

A

CYP3A4 Inducers

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13
Q

Ticlodipine

A

CYP3A4 Inducers

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14
Q

Bosentan

A

CYP3A4 Inducers

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15
Q

Orlistat

A

CYP3A4 Inducers

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16
Q

St Johns Wort

A

CYP3A4 Inducers

17
Q

Echinacea

A

CYP3A4 Inducers

18
Q

Inhibits MRP2 Transporter (2)–> Decrease Mycophenolate Concentrations

A

Cyclosporine
Tacrolimus (lower extent)

19
Q

Bind MPA in the GI tract and lower AUC

A

Cholestyramine and Bile Acid Resins

20
Q

Antibiotics which lower MPA AUC

A

Norfloxacin & Metronidazole
Amoxicillin with Clavulanic Acid
Rifampin
Ciprofloxacin

NARC

21
Q

Compete with MPAG for tubular secretion. LEading to increase MPA concentrations.

A

Acyclovir
Ganacyclovir
Cotrimoxazole

22
Q

____ lowers the efficacy of oral contraceptive.

A

Mycophenolate.

23
Q

Phenytoin and Aspirin bind albumin increasing the concentration of ____

A

Mycophenolate

24
Q

PK studies show that steroids increase ____ metabolism leading to lower concentrations.

A

MPA.

25
Q

Glucocorticoid Inhibitors

A

Oral Contraceptives
Naproxen
Estrogens
Macrolides
Isoniazid
Cyclosporin
Ketoconazole

ONEMIC

26
Q

Glucocorticoid Metabolism inducers

A

Phenytoin
Phenobarbital
Rifampin
Carbamazepine
Ephedrine

27
Q

Drugs induced by glucocorticoids.

A

Tacrolimus
Mycophenolate
Cyclosporine

28
Q

Drugs that increase hypokalemia risk with steroids.

A

Diuretics
Amphotericin
Digoxin.

Immunology (5 decks)

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