Immunology: Major Histocompatibility Complex Proteins Flashcards
1
Q
A region of highly polymorphic genes whose products are expressed on the surfaces of a variety of cells
A
MHC (Major Histocompatibility Complex)
2
Q
Products of MHC
A
Major histocompatibility antigens
3
Q
From where was MHC discovered?
A
Tissue transplantation (1940s)
4
Q
What is MHC called in mice?
A
H-2
5
Q
What is MHC called in humans?
A
HLA (Human Leukocyte Antigens)
6
Q
MHC is important in controlling immunologic responses called?
A
MHC restriction
7
Q
HLA molecules encoded for genes on the MHC fall into 2 classes
A
- MHC Class I antigens
- MHC Class II antigens
8
Q
MHC Class I antigens
A
- HLA-A
- HLA-B
- HLA-C
9
Q
MHC Class II antigens
A
HLA
- Dr
- DP
- DQ
10
Q
The gene that codes for the HLA antigens are located on which chromosome?
A
6
11
Q
HLA-A has how many recognized alleles?
A
218
12
Q
HLA-B has how many recognized alleles?
A
439
