Immunology Lecture 6_Innate immune response Flashcards
1
Q
What is found in the nutrophils of people with Chediak Higashi syndrom?
A
because people with this syndrom have no phagolysosomal function, their phagocytes (including nutrophils) have inclution bodies
2
Q
what is the ligand for TLR-4
A
LPS
3
Q
what is the ligand for TLR-9
A
CpG DNA
4
Q
What two major transcription factors are activated by TLR through signal transduction?
A
NF-KB which promotes inflamation and IRF 3 and 7 which promotes anti viral interferons (IFN alpha and beta)
5
Q
how do NK cells recognize self cells from invadors
A
through the detection of class 1 MHC
