Immunology II - Mclean. Only target questions

Question 1

which antibody involved with basophils mast cells eosinophils?

anaphylaxis, breathing problems.

Answer 1

IgE

Question 2

which antibodies in all 4 types of hypersensitive reactions?

Answer 2

Type I: IgE
Type II: IgG
Type III: IgG + soluble antigen
Type IV: none. *** Helper t cells / macrophages involved. AKA delayed-type hypersensitivity

Question 3

complement components are soluble proteins produced by…

after cleavage of C4 9complement)…

Answer 3

liver. Many complement components are zymogens (inactive form of enzyme) ***

C4 -> C4b (large) and C4a (small). Larger has enzymatic activity. Small = inflammation.

Question 4

antibody transfer of IgA and IgG

Answer 4

IgA through breast milk
IgG across placenta

Question 5

What are the inflammatory cytokines:

Answer 5

IL-1, IL-6, TNFa. Macrophages secrete this.

Question 6

Which mitogen stimulates both B and T cells?

Answer 6

Pokeweed mitogen.

Question 7

Order of potency

Answer 7

C5a > C3a > C4a

Question 8

pleiotropic:
redundancy:
synergy:

Answer 8

pleiotropic: one cytokine resulting in multiple effects
redundancy: multiple cytokines resulting in one effect
synergy: 2 cytokines working together to produce one effect.

Question 9

Classical pathway

Answer 9

Triggered by antibodies bound to surface of pathogen

Question 10

Alternative pathway:

Answer 10

triggered directly by components of bacterial cell surfaces. Dont need antibodies!

Question 11

Lectin-mediated pathway:

Answer 11

triggered by mannose binding proteins that are bound to molecules on the surface of pathogens.