Immunology - Cytokines Flashcards
What secretes IL-1
Macrophages
Function of IL-1
Acute inflammation
Induces fever
What secretes IL-2
Th1 cells
Function of IL-2
Stimulates growth and differentiation of T cell response
What secretes IL-4
Th2 cells
Function of IL-4
Stimulates proliferation and differentiation of B cells Causes class switching to IgE
What secretes IL-5
Th2 cells
Function of IL-5
Stimulate production of eosinophils
What secretes IL-6
Macrophages, Th2 cells
Function of IL-6
Stimulates differentiation of B cells
Induces fever
What secretes IL-10
Th2 cells
Function of IL-10
Inhibits Th1 cytokine production
Also known as human cytokine synthesis inhibitory factor and is an ‘anti-inflammatory’ cytokine
What secretes IL-12
Dendritic cells, macrophages, B cells
Function of IL-12
Activates NK cells and stimulates differentiation of naive T cells into Th1 cells
What secretes TNFa
Macrophages