Immunology - Cytokines Flashcards

1
Q

What secretes IL-1

A

Macrophages

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2
Q

Function of IL-1

A

Acute inflammation

Induces fever

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3
Q

What secretes IL-2

A

Th1 cells

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4
Q

Function of IL-2

A

Stimulates growth and differentiation of T cell response

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5
Q

What secretes IL-4

A

Th2 cells

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6
Q

Function of IL-4

A
Stimulates proliferation and differentiation of B cells
Causes class switching to IgE
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7
Q

What secretes IL-5

A

Th2 cells

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8
Q

Function of IL-5

A

Stimulate production of eosinophils

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9
Q

What secretes IL-6

A

Macrophages, Th2 cells

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10
Q

Function of IL-6

A

Stimulates differentiation of B cells

Induces fever

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11
Q

What secretes IL-10

A

Th2 cells

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12
Q

Function of IL-10

A

Inhibits Th1 cytokine production

Also known as human cytokine synthesis inhibitory factor and is an ‘anti-inflammatory’ cytokine

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13
Q

What secretes IL-12

A

Dendritic cells, macrophages, B cells

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14
Q

Function of IL-12

A

Activates NK cells and stimulates differentiation of naive T cells into Th1 cells

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15
Q

What secretes TNFa

A

Macrophages

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16
Q

Function of TNFa

A

Induces fever

Neutrophil chemotaxis

17
Q

What secretes IFNy

A

Th1 cells

18
Q

Function of IFNy

A

Activates macrophages

19
Q

What do macrophages secrete?

A

IL-1
IL-6
IL-12
TNFa

20
Q

What do TH1 cells secrete?

A

IL2

IFNy

21
Q

What do TH2 cells secrete?

A

IL-4
IL-5
IL-6
IL-10

22
Q

What do dendritic cells secrete?

A

IL-12

23
Q

What do B cells secrete?

A

IL-12