Immunology Complement

Question 1

C1 Inhibitor

Answer 1

Inactivates C1s and C1r or MASP1 and MASP2. Deficiency can lead to HAE

Question 2

Factor I

Answer 2

Serine protease that mediates enzymatic inactivation of C3b and C4b. No C3 convertase. Alternative pathway.

Question 3

Factor I needs cofactors like

Answer 3

MCP, CR1, FH or C4BP

Question 4

CD59

Answer 4

Prevents MAC assembly (NO C9)

Question 5

DAF diseases

Answer 5

(CD55) Paraxysmal nocturnal hemogloburinia

Question 6

C3 diseases

Answer 6

Suspec. capsulated bacteria

Question 7

C1,C2 and C4 diseases

Answer 7

immune complex dx

Question 8

Factor D/Properdin dx

Answer 8

Suspec. to capsulated bacteria

Question 9

Neisseria meningitidis stems from

Answer 9

Deficiencies in MAC formation C5 to C9 OR Deficiencies in AP like factor B and properdin

Question 10

CH50 and AC50 abnormal leads to

Answer 10

C3 defect or in terminal pathway

Question 11

CH50 abnormal

Answer 11

CP defect in C1, C2 or C4

Question 12

AC50 abnormal

Answer 12

Ap defect in Factor D, B or Properdin

Question 13

CD55 and CD59

Answer 13

Essential surface proteins that are anchored to GPI for health. Protect blood cells from complement.

Question 14

What are the soluble complement modulators?

Answer 14

Factor I, Factor H and C4BP