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SFM > Cell Signaling > Flashcards

Cell Signaling Flashcards

1
Q

Receptor recycling can be undergone via two methods

A

Fast (Rab4) or Slow (Rab11)

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2
Q

Receptor destruction can be undergone via

A

Late Endosomes (Rab7, Rab9) and Lysosome (Lamp-1)

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3
Q

Gs

A

Signal molecule ligand

Stimulates Adenylate Cyclase

GTP hits AC to activate cAMP–>PKA—> P downstream

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4
Q

Gi

A

Signal molecule ligand

GTP hits AC to inactive cAMP

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5
Q

Gt

A

Light signal molecule

GTP hits cGMP phosphodiesterase to activate cGMP–> 5 GMP

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6
Q

Gq

A

Signal molecule ligand

GTP hits Phospholipase C which splits it into IP3 and PKC.

IP3 opens Calcium channel, activates PKC via Ca and also activates calmodulin.

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7
Q

Gs physiological ligands

A

Epinephrine and B-adgrenergic receptor and Histamine

These are stimulations

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8
Q

Gi physiological ligands

A

Epinephrine/norepinephrine and alpha-adrenergic receptor and Dopamine

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9
Q

Gq ligand

A

acetycholine

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10
Q

Gt ligand

A

Light

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11
Q

Epinephrine or B adrenergic receptor binding to GPCR causes

A 
Relaxation of bronchials and intestinal smooth muscle
Contraction of heart
Breakdown of TGL
Breakdown of glycogen
Glycolysis
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12
Q

Histamine binding to GPCR causes

A

Bronchoconstriction and symptoms of allergy reactions

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13
Q

How does cGMP PDE inhibitors work?

A

They increase conc. of cellular cGMP which prolongs its effect. Smooth muscle relaxation and vasodilation.

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14
Q

Cholera toxins

A

Prevents inactivation of Gs

Add ADP ribosylation to Gs, always active GTPase, AC hyperactive, Making lots of cAMP activating CFTR, Cl- channels open. Loss of electrolytes and water, diarrhea.

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15
Q

Pertussin toxin

A

Prevents act. of Gi. Less inhibition of AC and over production of cAMP. Whooping cough

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16
Q

Nitric Oxide

A

Diffuses to neighboring muscles and act. guanylate cyclase leading to production of cGMP. Causes smooth muscle relaxation and vasodilation.

17
Q

Antihistamines

A

treat allergies by inhibiting GPCR

18
Q

Cancers stemming from G proteins mutations such as

A

RAS, GEFs or GAPs

19
Q

How does Herceptin control cancer?

A

Herceptin targets HER2 gene which is a family of the RTK

SFM (7 decks)

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