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Step Uno Part Dos > Immunology Cell Surface Markers > Flashcards

Immunology Cell Surface Markers Flashcards

1
Q

CD16

A

NK cells, binds Fc region of bound Ig

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2
Q

What makes Th1

A

IL-12

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3
Q

What makes Th2

A

IL-4

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4
Q

What makes Th17

A

TGF-beta and IL-6

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5
Q

What makes Treg

A

TGF-beta

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6
Q

CD28

A

T cells, binds B7 on APCs

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7
Q

CD40

A

On B cells, binds CD40L on T cells (CD4+)

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8
Q

Th1 secretes

A

IFN-gamma

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9
Q

TH2 secretes

A

IL-4, IL-5, IL-6 (stEAK), IL-10 and IL-13

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10
Q

Inhibits Th1

A

IL-4 (b/c it activates macs and CD8, don’t need B cells!) and IL-10 (ten is zen)

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11
Q

Inhibits Th2

A

IFN-gamma

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12
Q

Th2 function

A

Recruits eosinophils for parasite defense and promotes IgE production by B cells

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13
Q

Treg cell sruface markers

A

CD3, CD4, CD25 (alpha chain of IL-2 receptor), and transcription factor FOXP3

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14
Q

Tregs secrete

A

IL-10 and TGF-beta

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15
Q

Induces acute phase reactants

A

IL-1 and IL-6, TNF-alpha and IFN-gamma

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16
Q

PMN chemotactic agents

A

LTB4 (PMNs get b4 everyone else), IL-8 (clean up on aisle 8), C5a

17
Q

IL-12 function

A

Activates Th1 and NK cells

18
Q

What do macrophages secrete

A

IL-1, IL-6, IL-8, IL-12, TNF-alpha (they light the fire, get the cleanup crew, activate Th1, then burn it all down)

19
Q

All T cells secrete

A

IL-2 (T) and IL-3 (Bone-Granulocyte/Macrophage-CSF)

20
Q

CD3

A

On All T cells: associated with TCR for signal transduction

21
Q

CD28

A

On All T cells, binds B7 on APC

22
Q

CD40 Ligand

A

On Helper Ts

23
Q

CD19

A

B cells

24
Q

CD20

A

B cells

25
Q

CD21

A

B cells, EBV receptor

26
Q

CD40

A

B cells and macrophages

27
Q

B7

A

B cells and macrophages

28
Q

CD14

A

Macrophages

29
Q

CD16

A

NK cells, binds Fc of IgG

30
Q

CD56

A

Unique marker for NK

31
Q

CD14 reaction with bacteria

A

Binds endotoxins/lipopolysaccharide directly stimulating macrophages

32
Q

Th17 function

A

Activated in autoimmune diseases, secrete IL-17

Step Uno Part Dos (7 decks)

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