Immunology Cell Surface Markers Flashcards
CD16
NK cells, binds Fc region of bound Ig
What makes Th1
IL-12
What makes Th2
IL-4
What makes Th17
TGF-beta and IL-6
What makes Treg
TGF-beta
CD28
T cells, binds B7 on APCs
CD40
On B cells, binds CD40L on T cells (CD4+)
Th1 secretes
IFN-gamma
TH2 secretes
IL-4, IL-5, IL-6 (stEAK), IL-10 and IL-13
Inhibits Th1
IL-4 (b/c it activates macs and CD8, don’t need B cells!) and IL-10 (ten is zen)
Inhibits Th2
IFN-gamma
Th2 function
Recruits eosinophils for parasite defense and promotes IgE production by B cells
Treg cell sruface markers
CD3, CD4, CD25 (alpha chain of IL-2 receptor), and transcription factor FOXP3
Tregs secrete
IL-10 and TGF-beta
Induces acute phase reactants
IL-1 and IL-6, TNF-alpha and IFN-gamma
PMN chemotactic agents
LTB4 (PMNs get b4 everyone else), IL-8 (clean up on aisle 8), C5a
IL-12 function
Activates Th1 and NK cells
What do macrophages secrete
IL-1, IL-6, IL-8, IL-12, TNF-alpha (they light the fire, get the cleanup crew, activate Th1, then burn it all down)
All T cells secrete
IL-2 (T) and IL-3 (Bone-Granulocyte/Macrophage-CSF)
CD3
On All T cells: associated with TCR for signal transduction
CD28
On All T cells, binds B7 on APC
CD40 Ligand
On Helper Ts
CD19
B cells
CD20
B cells
