Cholesterol Diseases and Path Flashcards
1
Q
Chylomicron remnants are
A
Mostly depleted of triacylglycerols
2
Q
How does IDL become LDL
A
Remaining TGs are removed by hepatic lipase in the peripheral tissue.
3
Q
Type I dyslipidemia
A
Hyper-Chylomicronemia [Type I because it’s the first thing in the pathway] AR. Can’t breakdown chylomicrons: Absent LPL or ApoC-II. Super high TGs, chylomicrons, and chol. so pancreatitis, hepatosplenomegaly, and eruptive/pruritic xanthomas. No atherosclerosis risk.
4
Q
Type IIa dyslipidemia
A
Familial hypercholesterolemia. AD.
No LDL receptors, so accelerated atherosclerosis, tendon xanthomas, and corneal arcus
5
Q
Type IV dyslipidemia
A
Hypertriglyceridemia. AD.
Lots of VLDL and Tg. Liver produces too much VLDL. Get pancreatitis.
