Immunology-Antigen Processing and Presentation

Question 1

MHC class I

Answer 1

expressed on almost all nucleated cells (not neurons of CNS)

membrane-assoc. heavy chain made of a1, a2, and a3 bound to secreted light chain

present antigen to TCR of CD8 T cells

only expressed when associated with peptide at surface

folded so that a1 and a2 form antigen binding groove (binds 8-10 AA)

Question 2

MHC class II

Answer 2

expressed mainly on macrophages and B lymphocytes

interacts with CD4 T cells

Question 3

What happens when a T cell reacts to a foreign MHC rather than a self MHC?

Answer 3

rejection