Immunology and Infection Flashcards
What is the function of IL-2?
Maturation of cytotoxic T cells (released by CD4 cells)
What is the function of IL-4?
Causes B-cell maturation into plasma cells (released by CD4 cells)
Where do T cells come from and what kind of mediated immunity are they involved in?
Thymus. Involved in cell mediated immunity. Require MHC classes for activation.
What are the primary lymphoid organs?
liver, bone thymus
What is the function of of IgD?
This is a membrane bound receptor on B cells that serves as antigen receptor
What is the largest antibody?
IgM
Describe type I-IV hypersensitivity reactions.
I: immediate, IgE mediated
- ex. bee sting, peanut, hay fever
II: IgG or IgM mediated, these ab react with cell-bound antigen
-ex. ABO incompat, hyperacute reaction, MG
III: Immune complex
- Serum sickness, SLE
IV: Delayed hypersensitivity
- TB skin test, contact dermatitis
-only reaction not to involve Ab, tests cell-mediated immunity
WHen do you give tetanus toxoid vs. tetanus immune globulin?
Toxoid: Give in non-tetanus prone wounds if <3 doses given or >10 years; Give always in tetanus prone wounds if unless pt got >3 doses or its been <5 years since last
Immune globulin:
- Give only in tetanus prone wounds in patients that have not been immunized