Cell Biology & Hematology Flashcards
What types of molecules are ABO blood type antigens?
Glycolipids
What kind of molecules are HLA-type antigens?
Glycoproteins
What phase of the cell cycle is the most varible?
G1 – determines cell cycle length
What are the products of glycolysis?
2 ATP and 2 pyruvate
(Pyruvate enters citric acid cycle and electron transport chain to generate ATP)
Do RBC’s contain nuclear materials?
No
What are the three responses to vascular injury?
Vasoconstriction, platelet adhesion, thrombin generation
What factor is common amongst the intrinsic and extrinsic pathway?
Factor X
What are the intrisic and extrinsic pathways?
Intrinsic:
XI –> VIII–> X + V which leads to conversion of prothrombin (II) to thrombin which converts fibrinogen to fibrin
Extrinsic Pathway: Factor VII + X leads to the same conclusion
What is the mechanism of action of heparin?
Binds AT III to inactivate thrombin so you don’t get conversion of fibrinogen to fibrin
What are the mechanisms of action of Protein C and S?
C: degrades fibrin
S: protein C cofactor (lead to anticoagulation
What is K-centra?
PCC or prothrombin complex concentrate (factor II)
Which factor is the only one not synthesized by the liver?
Factor VIII (comes from endothelium along with vWF)
Highest concentration is seen in cryoprecipitate. These can be released in response to DDAVP or estrogens
How would you treat the following based on a TEG?
Elevated R time
Elevated K time
Low angle
Low MA
High LY30
R: FFP
K: Cryo
Low angle: Cryp
Low MA: Platelets
High LY30: TXA
*Think F - C - C- P
What is the most common congenital bleeding disorder?
vWF
I and II are AD
III is AR
I is most common tx w/ DDAVP
II: Cryo
III; Cryo
What is hemophilia A?
VIII deficiency (prolonged PTT)
Sex-linked recessive
