Immunology

Question 1

Wiskott-aldrich Syndrome symptoms

Answer 1

EXITS

Eczema
X-linked
Immunodeficiency
Thrombocytopenia
SMALL platelets *pathopneumonic for Thrombocytopenia secondary to Wiskott-aldrich

Question 2

Bloom syndrome symptoms

Answer 2

Deficiency of DNA ligase repair

symptoms:
small stature
telangiectasia
CNS abnormalities
immunodeficiency
*high association with leukemias

Question 3

Chediak-Higashi

1) what
2) symptoms

Answer 3

1) Impaired lysosome degranulation

2) recurrent cutaneous and sinopulmonary infections
partial oculocutaneous albinism (in skin hair and eyes)
intellectual disability
progressive peripheral neuropathy
* peripheral smear shows giant granules

Question 4

Catalase + organisms

Answer 4

S. aureus
Serratia marcescens
Burkholderia
Aspergillus
Chromobacterium
Nocardia

Question 5

T-cell deficiency symptoms

Answer 5

Intracellular organisms and opportunistic infection
bacteria: salmonella, syphilis
Mycobacteria
Virus: CMV, HSV, VZV, EBV
Fungi: Candida, aspergillus, cocci, cryptococcus, histoplasmosis
Protozoa: PJP, toxoplasmosis, mircosporidiosis

Question 6

B-cell deficiency symptoms

Answer 6

Recurrent sinopulmonary infections

• Bacteria: S pnuemoniae, H- influenzae, Staph aureus
• Virus: enterovirus (no IgA)
• protozoa: Giardia (no Ia=gA, no IgE)

Question 7

Phagocytosis disorder symptoms

Answer 7

Skin and organ abscesses
bacteria: staph aureus
Catalase positive organisms

Question 8

Complement deficiency

Answer 8

Overwhelming sepsis
Early complement: Pyogenic infections
Last complement: Neisseria meningitidis