Hematology

Question 1

Mentzer index

Answer 1

MCV/RBC

>13= iron deficiency
<13= thalassemia

Question 2

pernicious anemia diagnosis

Answer 2

anti-IF antibiodies + low B12+ high serum methylmalonic acid (MMA)

Question 3

Warm vs cold autoimmune hemolytic disease

Answer 3

Warm- coombs positive because it is caused by IgG.
primary or secondary. (secondary to penicillins, cephalosporins, NSAIDS, lupus)

Cold- Coombs negative because it is caused by IgM (secondary to mycoplasma and EBV)

Question 4

Fanconi anemia symptoms

Answer 4

• usually occurs at 8 to 9 years old
• macrocytic anemia (can have pancytopenia)
• Absent thumbs, abnormal radii, microcephaly, short stature, cafe-au-lait spots, and renal anomalies

Question 5

red cell aplasia workup

Answer 5

parvovirus 19, EBV and CMV

Question 6

diamond blackfan anemia

Answer 6

• macrocytic anemia
• usually presents at < 1 year old
• thumb abnormalities, short stature, renal anomalies, glaucoma, hypogonadism, webbed neck, congenital heart disease and intellectual disability

Question 7

Type of bleeding seen by syndrome group:

1) platelet deficiency and platelet disorder
2) vasculitis
3) coagulation disorders

Answer 7

1) petechiae, ecchymosis and mucocutaneous bleeding
2) palpable purpura
3) deep tissue bleeding

Question 8

Treatment for hemophilia A

Answer 8

1) mild disease DDAVP ( released stored factor 8 from endothelial cells)
2) moderate to severe disease: factor 8 concentrate

Question 9

protein C function

Answer 9

this of protein C as the protector around our natural TPA