Immunology

Question 1

What is the primary way the keratin layer acts as an immunological defense?

Answer 1

By being a physical barrier

Question 2

How can keratinocytes recognize pathogens?

Answer 2

Via surface cell receptors

Question 3

How can keratinocytes act against pathogens?

Answer 3

By releasing antimicrobial peptides to directly kill pathogens
By producing of cytokine and chemokines

Question 4

How do Langerhans cells contribute to the immunological response?

Answer 4

By presenting antigens to t-cells within the lymph nodes

Question 5

What type of cell is a Langerhans cell?

Answer 5

Dendritic cell

Question 6

What type of T-cell is mostly found in the epidermis?

Answer 6

CD8+

Question 7

What type of T-cells are found in the dermis?

Answer 7

CD8+

CD4+

Question 8

What type of CD4+ T-cells are found in psoriasis?

Answer 8

Th1 and Th17

Question 9

What type of CD4+ T-cells are found in atopic dermatitis?

Answer 9

Th2 and Th17

Question 10

Name the 2 main types of dendritic cells found in the dermis

Answer 10

Dermal

Plasmacytoid

Question 11

What is the function of a dermal dendritic cell?

Answer 11

Antigen presentation and release of cytokines and chemokines

Question 12

What is the function of plasmacytoid dendritic cells?

Answer 12

The production if IFN-alpha

Question 13

Which type of dendritic cell is found in the dermis in cases of skin disease?

Answer 13

Plasmacytoid

Question 14

Besides from dendritic cells what other types of immune cells are found in the dermis?

Answer 14

Macrophages
Neutrophils
Mast cells

Question 15

What mediates a type I hypersensitivity reaction?

Answer 15

IgE

Question 16

What mediates a type II hypersensitivity reaction?

Answer 16

Antibodies

Question 17

What mediates a type III hypersensitivity reaction?

Answer 17

Immune complex mediated

Question 18

What mediates a type IV hypersensitivity reaction?

Answer 18

Cell mediated
(This is a delayed type reaction)