Immunology Flashcards
Name the parts of the GI tract associated with lymphoid tissue
Adenoid Tonsil Small intestine Appendix Large intestine
The small and large intestine consist of villi and crypts. True/False?
False
Only SI has both - LI only has crypts (no villi)
What do goblet cells secrete?
Mucous
Are goblet cells found in both the small and large intestine?
Yes
Paneth cells are found in the small intestine but not the large intestine. True/False?
True
What do paneth cells secrete?
Defensins (anti-microbial peptide)
Peyer’s patches contain immune cells which sample antigens and activate the immune response in the small and large intestine. True/False?
False
Only in the small intestine (not found in large intestine)
Bacterial load of large intestine > bacterial load of small intestine. True/False?
True
Where does antigen capture and activation, mediated by dendritic cells, take place?
Peyer’s patches
Also across the epithelium
Once a dendritic cell has captured an antigen at the membrane, where does it migrate towards?
Lymph node to present to T cells
Which type of cell is part of the epithelium covering Peyer’s patches?
M cell
What are the homing receptors which mediate T cell transport into the Peyer’s patch?
CCR7L-selectin
What do T cells do in the Peyer’s patch?
Become activated by antigen-bound dendritic cell
They lose CCR7 and can no longer recirculate
From the Peyer’s patch, where do activated (effector) T and/or B cells go?
Drain via mesenteric lymph nodes into thoracic duct
Which receptors, on immune cell and endothelium, aid transport of effector immune cell out of the gut?
α4-β7 integrin on T cell
MAdCAM-1 on endothelium
