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Medicine > Immunology > Flashcards

Immunology Flashcards

1
Q

CD2 (LFA-2)

A

Adhesion molecule

Expressed by T cells, NK cells

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2
Q

CD3

A

Signal transduction by TCR

Expressed by T cells

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3
Q

CD4

A

Co-receptor for TCR-MHC class II (+ HIV rec)

Expressed by Th cells, monocytes, macrophages

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4
Q

CD8

A

Co-receptor for MHC class I-restricted T cells

Expressed by Tc cells

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5
Q

CD14 (LPS rec)

A

Binds LPS

Expressed by monocytes, macrophages, granulocytes

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6
Q

CD16 (Fc rec)

A

Opsonization ADCC

Expressed by NK cells, neutrophils + macrophages

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7
Q

CD18

A

Cell adhesion molecule
(missing in leukocyte adhesion def)

Expressed by Leukocytes

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8
Q

CD19

A

Co-rec w/ CD21 for B cell activation

Expressed by B cells

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9
Q

CD20

A

Unknown role in B cell activation

Expressed by most/all B cells

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10
Q

CD21 (CR2, C3d rec)

A

Rec for Complement fragment C3d
Forms co-rec complex w/ CD19
Epstein-Barr virus (EBV) rec

Expressed by mature B cells

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11
Q

CD25

A

Alpha chain of IL-2 rec

Expressed by activated Th cells + Treg

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12
Q

CD28

A

Binds w/ costimulatory molecule B7

Expressed by T cells

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13
Q

CD34

A

Cell-cell adhesion, binds L-selectin

Expressed by hematopoietic precursors, endothelial cells in HEV

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14
Q

CD40

A

Binds w/ CD40L, role in activation of B cells, macrophages, dendritic cells, endothelial cells

Expressed by B cells, macrophages, dendritic cells, endothelial cells

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15
Q

CD56

A

Cell adhesion

Expressed by NK cells

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16
Q

CD152 (CTLA-4)

A

Negative regulation
Competes w/ CD28 for B7 binding

Expressed by activated T cells

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17
Q

IL-1 Effects on:

Th cells

A

Costimulates activation

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18
Q

IL-1 Effects on:

B cells

A

Maturation + clonal expansion

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19
Q

IL-1 Effects on:

NK cells

A

Enhances activity

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20
Q

IL-1 Effects on:

endothelial cells

A

Increases expression of ICAMs

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21
Q

IL-1 Effects on:

Neutrophils + Macrophages

A

Chemotaxis

22
Q

IL-1 Effects on:

Hepatocytes

A

Induces acute-phase protein synthesis

23
Q

IL-1 Effects on:

Hypothalamus

A

Induces fever

24
Q

IL-1 Secreted by

A

Monocytes, Macrophages, Dendritic cells

B cells

Endothelial cells

25
Q

IL-2

A

Induces Th + Tc proliferation + enhances activity

Secreted by Th cells

26
Q

IL-3

A

Induces hematopoietic growth + differentiation

Secreted by Th cells + NK cells

27
Q

IL-4

A

Costim activation of Ag-primed B cells
Induces proliferation + differentiation of activated B cells
Induces B cell class switch to IgE

Secreted by Th2 cells

28
Q

IL-5

A

Induces Eosinophil differentiation in Bone Marrow

Secreted by Th2 cells + Mast cells

29
Q

IL-6 Secreted by

A

Monocytes, Macrophages

Th2 cells

Bone marrow stromal cells

30
Q

IL-6 Effects on:

B cells + Plasma cells

A

Promotes differentiation of B cells to Plasma cells

Stimulates Plasma cell Ab secretion

31
Q

IL-6 Effects on:

Myeloid stem cells

A

Helps promote differentiation

32
Q

IL-6 Effects on:

Hepatocytes

A

Induces acute-phase protein synthesis

33
Q

IL-7

A

Induces Lymphoid stem cells to differentiate to progenitor B + T cells

Secreted by Bone marrow, Thymic stromal cells

34
Q

IL-8

A

Neutrophil chemokine, induces adherence to endothelium + extravasation

Secreted by Macrophages, endothelial cells

35
Q

IL-10

A

Inhibits cytokine production by Th1 cells
Inhibits co-stim molecules on Macrophages

Secreted by Th2 cells, Treg cells

36
Q

IL-11

A

Increases Platelet count in Bone Marrow

Secreted by Bone Marrow stroma

37
Q

IL-12 Effects on:

Activated CD8+ cells

A

Synergy w/ IL-2 to induce differentiation to Tc cells

Secreted by Macrophages, B cells

38
Q

IL-12 Effects on:

Activated Th1 cells + NK cells

A

Induces proliferation of Activated Th1 cells + NK cells

Secreted by Macrophages, B cells

39
Q

IL-13

A

Induces B cell class switch to IgE

Secreted by Th2 cells

40
Q

IL-17 Effects on:

Fibroblasts, Endothelial cells, Macrophages

A

Increases inflammation
Chemotaxis to Neutrophils
Induces IL-1, IL-6, IL-8, TNF alpha, TGF beta

Secreted by Th17 cells

41
Q

IL-18

A

Stimulates Th cells, NK cells, IFN gamma synthesis

Secreted by Macrophages

42
Q

IL-22

A

Stabilizes Endothelial barrier
Induces Endothelial antimicrobial secretion

Secreted by Th17 cells

43
Q 
IFN alpha (type I)
(Interferon alpha)
A

Inhibits viral replication in uninfected cells

Secreted by Leukocytes

44
Q 
IFN beta (type I)
(Interferon beta)
A

Inhibits viral replication in uninfected cells

Secreted by Fibroblasts

45
Q 
IFN gamma (type II)
(Interferon gamma)
A 
Enhances Macrophage activity
Induces expression of MHC class I + II
Induces B cell class switch to IgG2a
Blocks IL-4 induced B cell class switch to IgE + IgG1
Blocks Th2 cell proliferation

Secreted by Th1, Tc, NK cells

46
Q

TGF beta

Transforming Growth Factor beta

A

Induces B cell class switch to IgA

Secreted by Platelets, Mast cells, Macrophages, Lymphocytes

47
Q

TNF alpha

Tumor Necrosis Factor alpha

A

Cytotoxic effect on tumor cells
Induces cytokine secretion in inflammatory cells
Causes cachexia of chronic inflammation

Secreted by Macrophages, NK cells

48
Q

TNF beta

Tumor Necrosis Factor beta

A

Cytotoxic effect on tumor cells
Enhances phagocytic activity in Neutrophils + Macrophages

Secreted by Th1 + Tc cells

49
Q

G-CSF

Granulocyte Colony Stimulating Factor

A

Induces proliferation of bone marrow granulocyte precursors
Rx for neutropenia post-ablative chemotherapy

Secreted by Th cells + Macrophages

50
Q

GM-CSF

Granulocyte-Macrophage Colony Stimulating Factor

A

Induces proliferation of bone marrow granulocyte + macrophage precursors
Rx for neutropenia post-ablative chemotherapy

Secreted by Th cells + Macrophages

Medicine (7 decks)

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