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Immunology Flashcards

1
Q

CD2 (LFA-2)

A

Adhesion molecule

Expressed by T cells, NK cells

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2
Q

CD3

A

Signal transduction by TCR

Expressed by T cells

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3
Q

CD4

A

Co-receptor for TCR-MHC class II (+ HIV rec)

Expressed by Th cells, monocytes, macrophages

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4
Q

CD8

A

Co-receptor for MHC class I-restricted T cells

Expressed by Tc cells

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5
Q

CD14 (LPS rec)

A

Binds LPS

Expressed by monocytes, macrophages, granulocytes

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6
Q

CD16 (Fc rec)

A

Opsonization ADCC

Expressed by NK cells, neutrophils + macrophages

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7
Q

CD18

A

Cell adhesion molecule
(missing in leukocyte adhesion def)

Expressed by Leukocytes

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8
Q

CD19

A

Co-rec w/ CD21 for B cell activation

Expressed by B cells

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9
Q

CD20

A

Unknown role in B cell activation

Expressed by most/all B cells

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10
Q

CD21 (CR2, C3d rec)

A

Rec for Complement fragment C3d
Forms co-rec complex w/ CD19
Epstein-Barr virus (EBV) rec

Expressed by mature B cells

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11
Q

CD25

A

Alpha chain of IL-2 rec

Expressed by activated Th cells + Treg

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12
Q

CD28

A

Binds w/ costimulatory molecule B7

Expressed by T cells

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13
Q

CD34

A

Cell-cell adhesion, binds L-selectin

Expressed by hematopoietic precursors, endothelial cells in HEV

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14
Q

CD40

A

Binds w/ CD40L, role in activation of B cells, macrophages, dendritic cells, endothelial cells

Expressed by B cells, macrophages, dendritic cells, endothelial cells

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15
Q

CD56

A

Cell adhesion

Expressed by NK cells

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16
Q

CD152 (CTLA-4)

A

Negative regulation
Competes w/ CD28 for B7 binding

Expressed by activated T cells

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17
Q

IL-1 Effects on:

Th cells

A

Costimulates activation

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18
Q

IL-1 Effects on:

B cells

A

Maturation + clonal expansion

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19
Q

IL-1 Effects on:

NK cells

A

Enhances activity

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20
Q

IL-1 Effects on:

endothelial cells

A

Increases expression of ICAMs

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21
Q

IL-1 Effects on:

Neutrophils + Macrophages

A

Chemotaxis

22
Q

IL-1 Effects on:

Hepatocytes

A

Induces acute-phase protein synthesis

23
Q

IL-1 Effects on:

Hypothalamus

A

Induces fever

24
Q

IL-1 Secreted by

A

Monocytes, Macrophages, Dendritic cells

B cells

Endothelial cells

25
IL-2
Induces Th + Tc proliferation + enhances activity Secreted by Th cells
26
IL-3
Induces hematopoietic growth + differentiation Secreted by Th cells + NK cells
27
IL-4
Costim activation of Ag-primed B cells Induces proliferation + differentiation of activated B cells Induces B cell class switch to IgE Secreted by Th2 cells
28
IL-5
Induces Eosinophil differentiation in Bone Marrow Secreted by Th2 cells + Mast cells
29
IL-6 Secreted by
Monocytes, Macrophages Th2 cells Bone marrow stromal cells
30
IL-6 Effects on: | B cells + Plasma cells
Promotes differentiation of B cells to Plasma cells Stimulates Plasma cell Ab secretion
31
IL-6 Effects on: | Myeloid stem cells
Helps promote differentiation
32
IL-6 Effects on: | Hepatocytes
Induces acute-phase protein synthesis
33
IL-7
Induces Lymphoid stem cells to differentiate to progenitor B + T cells Secreted by Bone marrow, Thymic stromal cells
34
IL-8
Neutrophil chemokine, induces adherence to endothelium + extravasation Secreted by Macrophages, endothelial cells
35
IL-10
Inhibits cytokine production by Th1 cells Inhibits co-stim molecules on Macrophages Secreted by Th2 cells, Treg cells
36
IL-11
Increases Platelet count in Bone Marrow Secreted by Bone Marrow stroma
37
IL-12 Effects on: | Activated CD8+ cells
Synergy w/ IL-2 to induce differentiation to Tc cells Secreted by Macrophages, B cells
38
IL-12 Effects on: | Activated Th1 cells + NK cells
Induces proliferation of Activated Th1 cells + NK cells Secreted by Macrophages, B cells
39
IL-13
Induces B cell class switch to IgE Secreted by Th2 cells
40
IL-17 Effects on: | Fibroblasts, Endothelial cells, Macrophages
Increases inflammation Chemotaxis to Neutrophils Induces IL-1, IL-6, IL-8, TNF alpha, TGF beta Secreted by Th17 cells
41
IL-18
Stimulates Th cells, NK cells, IFN gamma synthesis Secreted by Macrophages
42
IL-22
Stabilizes Endothelial barrier Induces Endothelial antimicrobial secretion Secreted by Th17 cells
43
``` IFN alpha (type I) (Interferon alpha) ```
Inhibits viral replication in uninfected cells Secreted by Leukocytes
44
``` IFN beta (type I) (Interferon beta) ```
Inhibits viral replication in uninfected cells Secreted by Fibroblasts
45
``` IFN gamma (type II) (Interferon gamma) ```
``` Enhances Macrophage activity Induces expression of MHC class I + II Induces B cell class switch to IgG2a Blocks IL-4 induced B cell class switch to IgE + IgG1 Blocks Th2 cell proliferation ``` Secreted by Th1, Tc, NK cells
46
TGF beta | Transforming Growth Factor beta
Induces B cell class switch to IgA Secreted by Platelets, Mast cells, Macrophages, Lymphocytes
47
TNF alpha | Tumor Necrosis Factor alpha
Cytotoxic effect on tumor cells Induces cytokine secretion in inflammatory cells Causes cachexia of chronic inflammation Secreted by Macrophages, NK cells
48
TNF beta | Tumor Necrosis Factor beta
Cytotoxic effect on tumor cells Enhances phagocytic activity in Neutrophils + Macrophages Secreted by Th1 + Tc cells
49
G-CSF | Granulocyte Colony Stimulating Factor
Induces proliferation of bone marrow granulocyte precursors Rx for neutropenia post-ablative chemotherapy Secreted by Th cells + Macrophages
50
GM-CSF | Granulocyte-Macrophage Colony Stimulating Factor
Induces proliferation of bone marrow granulocyte + macrophage precursors Rx for neutropenia post-ablative chemotherapy Secreted by Th cells + Macrophages

Medicine (7 decks)

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