Immunology Flashcards
are commensal bacteria presetn in the eye?
yes but not many
are there cheminal agents in the eye?
yes
what does the eye use for innate immunity? (3)
blnk reflex
physical/chemical properties of eye surface
limit exposure/size
the mucous layer of the eye is an anti-______?
anti- adhesive
what is present in tears that help with immunity of the eye?
lysozyme
lactoferrin and transferrin
tear lipids
angiogenin
secretory IgA
what are some immune cells in the eye?
neutrophils
macrophages
conjuctival mast cells
what is the principle APC for the external eye?
langerhans cells
langerhans are rich in which class of MHC molecules?
class II MHC
where are langerhans predominantly found in the eye?
corne-scleral limbus
less so in peripheral cornea
absent from central 1/3rd of cornea
what is the only part of the eye with lymphatic drainage?
conjuctiva- has specialised endothelial venules
which cells act as APCs in the conjuctiva?
dendritic cells
what is MALT? (found in conjuctiva aswell as gut)
Mucosa associated lymphoid tissue
the cornea and sclera are knwon as the ____ _______ ___
tough collagen coat
do the cornea and sclera contains lymphatics/lymphoid tissue?
NO- avascular also
the lacrimal gland contains more of which cells in comparison to the conjuctiva?
plasma cells (IgA) and CD8+T cells
the eye is described a _________ immune environment
downregulated
which sites in the eye are immune privileged?
cornea
anterior chamber
lens
vitreous cavity
subretinal space
what is ACAID?
Anterior Chamber Associated Immune Deviation
ACAID is an active process true/false?
true
what is sympathetic opthalmia?
bilateral granulomatous uveitis due to trauma/surgery in one eye
what are the priamry mediators thought to be in sympathetic opthalmia?
T cells
what is released in the eye after trauma/surgery that is then carried to lymphnodes activating T cells?
Intracolular Protein Antigens
what are the two waves of infiltrative cells in sympathetic opthalmia?
intial wave- CD4+ helper T cells
later wave- CD8+ cytotoxic T cells
the injured eye is known as the ‘______’ eye, and the fellow eye is known as the ‘__________’ eye
injured= exciting eye
fellow= sympathetic eye
describe dalen-fuchs nodule
epithelial cell clusters in retinal layers
keratoconjunctivitis sicca is known as what?
dry eyes
what are the 4 types of hypersensitivy reaction?
Type I- immediate hypersensitivity
Type II- direct cell killing
Type III- immune complex mediated
Type IV- delayed hypersensitivity
define chemosis
oedema of the conjuctiva
ocular cicatrical pemphigoid is an example of which type of hypersensitivity?
Type II
corneal melt is a type III/IV hypersensitivty reaction?
type III
