Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Dermatology > Immunology > Flashcards

Immunology Flashcards

You may prefer our related Brainscape-certified flashcards:
Dermatology Board Prep flashcards
1
Q

What can keratinocytes produce in response to pathogens?

A

AMPs which directly kill pathogens

Cytokines & chemokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are Birbeck granules characteristic of?

A

Langerhans cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Main type of T cell in epidermis

A

CD8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

T cell type in dermis

A

CD4 & CD8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

CD4 types associated w/ inflammation

A

Th1 - psoriasis
Th2 - atopic dermatitis
Th17 - psoriasis & atopic dermatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Purpose of Th1 cells & chemical mediators released

A

Activate macrophages

IL2, IFNgamma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Purpose of Th2 cells & chemical mediators released

A

Help B cells make Ab

IL4, IL5, IL6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which type of dendritic cell in the dermis is found in diseased skin? Which chemical mediator does it release?

A

Plasmacytoid dendritic cell (pDC)

IFNalpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are mast cells in the dermis activated by?

A

IgE, physical trauma, certain drugs, micro-organisms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

MHC class I presents (endogenous/ exogenous) antigens?

A

Endogenous

Class II presents exogenous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which 3 things in the body can psoriasis affect?

A

Skin, nails, joints

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What fraction of psoriasis pts have joint disease?

A

1/3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Immunopathogenesis of psoriasis

A
  1. Keratinocytes under stress
  2. Chemical signals activate DC, which migrate to the local draining lymph nodes to present to and activate T cells
  3. These T cells are drawn back from the circulation and attracted to the dermis by chemokines and secrete IL-17A/17F/22
  4. CD8 cells also contribute to the pathogenesis
  5. Dermal fibroblasts become involved, which release keratinocyte and epidermal growth factors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which gene mutation is atopic eczema associated with?

A

Fillagrin - associated w/ severe/early onset disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

AMP is reduced/increased in skin in atopic eczema?

A

Reduced

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Can atopic eczema be present at birth?

A

No, but frequently appears in 1st year of life

17
Q

What is Koebner phenomenon?

A

Skin lesions appearing on lines of trauma

18
Q

What is type I hypersensitivity mediated by?

A

IgE

19
Q

What are type II & III hypersensivities mediated by?

A

IgG, IgM

20
Q

What is type IV hypersensitivity mediated by?

A

Th1 cells (cell-mediated)

21
Q

How can ageing affect skin immune response?

A

Changes in skin structure (access)
Decreased ability to detect malignant cells – Cancer
Decreased ability to detect Ag – Infection risk
Decreased ability to distinguish “self” from “non-self” (tolerance) – Autoimmunity

22
Q

What is RAST?

A

A blood test using radioimmunoassay test to detect specific IgE antibodies

23
Q

What dosage of adrenaline is present in an epipen for children & adults?

A

Children - 150µg

Adults - 300µg

Dermatology (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions