Drug eruptions Flashcards
1
Q
What percentage of adverse drug reactions are cutaneous?
A
30% (3% of hospitalised pts)
2
Q
How do cutaneous drug eruptions present?
A
Sudden symmetric skin eruption
Usually resolves when drug is withdrawn (half-life of drug will play a role)
3
Q
Most common type of drug reaction
A
Exanthematous (eruptions or rashes are a prominent manifestation)
4
Q
Indicators of a potential severe exanthematous reaction
A
Involvement of mucous membrane and face. Facial oedema & erythema. Widespread confluent erythema. Fever (>38.5⁰C). Blisters, purpura, necrosis. Lymphadenopathy, arthralgia. Shortness of breath, wheezing.
5
Q
Drugs associated with exanthematous drug eruptions
A
Penicillins Sulphonamide antibiotics Erythromycin Streptomycin Allopurinol Anti-epileptics: carbamazepine NSAIDs Phenytoin Chloramphenicol
6
Q
Which drugs should be avoided in pts w/ urticaria?
A
NSAIDs and aspirin
7
Q
Bodybuilder w/ acne
A
Anabolic steroids
8
Q
Drugs that can cause bullous pemphigoid
A
ACE inhibitors, penicillin, furosemide
9
Q
Drugs associated w/ fixed drug eruptions
A
Tetracycline, doxycycline
Paracetamol
NSAIDS
Carbamazepine
