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Dermatology > Cancer > Flashcards

Cancer Flashcards

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Dermatology Board Prep flashcards
1
Q

What are the 6 hallmarks of cancer?

A 
Sustaining proliferative signalling
Evading growth suppressors
Activating invasion and metastasis
Enabling replicative immortality
Inducing angiogenesis
Resisting cell death
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2
Q

What are the 2 enabling hallmarks (or characteristics) of cancer?

A

Genome instability and mutation

Tumour-promoting inflammation

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3
Q

What are the 2 emerging hallmarks of cancer?

A

Avoiding immune destruction

Deregulating cellular energetics

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4
Q

At which checkpoint does p53 act?

A

G1

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5
Q

Mutations in which gene are associated with BCC development?

A

PTCH1

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6
Q

Which genes have been linked to familial melanoma?

A

CDKN2A

CDK4

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Dermatology (10 decks)

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