Immunology Flashcards
1
Q
what are antibodies molecularly
A
glycoproteins
2
Q
Hypersensitivity
A
1 - IgE - immediate
2 - antibody dependent, IgM, IgG
eg: haemolytic disease of the newborn, good pastures, pernicious anaemia
3 - deposition of immune complexes - Arthus reaction
4 - Delayed. T cell immunity e.g.: Mantoux
3
Q
Complement system
What are they
Where are they made
A
Glycoproteins - around 20
made in the liver
4
Q
How is the complement system activated
A
- C1 binding to an antibody which has been activated to an antigen
- C3 activation - independent of antibodies
- Mannose-lectin activation pathway
C3 is cleaved to form C3a
5
Q
NK cells
A
innate immunity lymphocytes Recognise failure to express MHC 1 Cytotoxic release performs and granzyme to cause apoptosis
6
Q
Examples of live attenuated vaccines
A
MMR
BCG
Polio (sabin)
7
Q
Examples of inactivated vaccines
A
hep A
pertussis
influenza
polio (salk)
8
Q
toxoid vaccines
A
tetanus and diptheria
9
Q
Example of subunit vaccine
A
Hep B
