Immunology Flashcards
What cells have MHC Class 1
All nucleated cells except for RBC
Langerhans Cell Histiocytosis
- Birbeck granules on EM = tennis racket shape within the cell
- don’t function well as APC
- children usually have this tumor and it presents as lytic bone lesions in the skull
- Tumor Marker S100 and CD1a
- can cause Interstital Restricitve Lung Disease
Immunizations
Live form of vaccines that can be given to HIV patients are MMR, yellow fever, and varicella vaccine as long as the patients CD4 count >200
- the benefits outweigh the risk
Autoantibodies
Pg 213
Host Protection against Mycobacterium Tuberculosis
- this occurs with interferon signaling
- specifically interferon gamma from macrophages
Leukocyte Adhesion Deficiency
- rare immunodeficiency resulting from a defect in CD18
- a common component in many integrity that is normally responsible for leukocyte adherence and transmigration through endothelial cells
- these patients present with delayed separation of the umbilical cord, recurrent cutaneous infections without pus formation and poor wound healing
Hepatitis A virus
- most commonly silent or sub clinical (anicteric) in young children but can also present as an acute self-limited illness characterized by jaundice, malaise, fatigue, nause, vomiting, right upper quadrant pain or an aversion to smoking
Transplant Rejection
make sure to look at pg 217
Immunosuppressant Drugs
217-220
S. Pyogenes M-protein
Major virulence factor for S. Pyogenes
- it inhibits phagocytosis and complement activation, mediates bacterial adherence, and is the target of type-specific humor immunity to S. Pyogenes
CD8 pathway
- the viral proteins are degrade by the ubiquitin pathway and then coupled to the MHC1 complex in the ER and then finally presented to CD8 T-cells
- uses ubiquitin lipase
Hemosiderin containing macrophages
- Heart failure cells that occur due to chronic heart failure
