Endocrine

Question 1

Glucocorticoid Toxicity

Answer 1

Cushing Syndrome
Diabetes
Osteoporosis
Glaucoma
Peptic Ulcers
Neuropsychiatric issues 
Tertiary adrenal insufficiency
Atrophy of adrenal cortex

Question 2

Aldosterone

Answer 2

Helps to regulate salt and water balance in the sweat glands and GI tract
Increased aldosterone secretion can occur with decreased sodium and decreased water volume

• high sodium can suppress aldosterone

Question 3

If some one has an aldosterone deficiency

Answer 3

• use fludrocortisone it stimulates the aldosterone receptor very avidly
• some synthetic glucocorticoids can have mineralocorcticoid activity

Question 4

Treatment of Pheochromocytoma

Answer 4

• give alpha blocker like phenoxybenzamine first
• then give beta blocker

If you give beta blocker without alpha then you can increase the hypertension but having uninhibited alpha vasoconstriction

Question 5

Adrenal Insufficiency

Answer 5

• can use metyrapone stimulation test = blocks the last step of cortisol synthesis (11-deoxycortisol –> cortisol)
• Normal response is decreased cortisol and compensatory increased ACTH
• in adrenal insufficiency ACTH remains decreased after test

Question 6

Tesamorelin

Answer 6

GHRH analog used to treat HIV associated lipodystrophy

Question 7

TRH

Answer 7

increases prolactin secretion