IMMUNOLOGY Flashcards
_______ is re-expressed after several days and activated and differentiated effector T cells then sense the S1P gradient and exit the node
S1PR1
-the exiting of T cells from the lymph nodes
What is the ligand and the function of receptor:ligand pair for L-selectin (native T-cells)
- Ligand on endothelial cell: PNAd
- Function: initial weak adhesion of naive T-cells to HEV in lymph node
What is the ligand on endothelial cell and the function of receptor:ligand pair of LFA-1 (beta2-integrin)?
- Ligand: ICAM-1
- Function: stable arrest on HEV in lymph node
What is the ligand on endothelial cells and function of receptor:ligand pair of E and P-selectin ligand? (activated memory cell)
- Ligand: E or P-selectin
- Function: initial weak adhesion of effector and memory T cells to cytokine activated endothelium at peripheral site of infection
What is the ligand on endothelial cell and function of receptor:ligand pair of LFA-1 (beta-integrin) or VLA-4 (beta1-integrin)?
- Ligand: ICAM-1 or VCAM-1
* function: stable arrest on cytokine-activated endothelium at peripheral site of infection
What chemokines are displayed on the surface of the HEV?
CCL19 and CCL21
As B-cells mature further, what chemokine receptor do they express? This promotes their movement into the white pulp in response to what chemokine?
1: CXCR5
2: CXCL13
Homing process requires what chemokines on HEV and what receptors on naive B cells?
- HEV: CXCL21 and CCL19/CCL21
- Naive B cells: CXCR4 and CCR7
In the stroma, B cells migrate into follicles driven by ____ recoginzed by ______ on naive B cells.
- CXCL12
2. CXCR5
What is the role of TNF, IL-1, chemokines?
Inflammation
What is the role of IFN-alpha and beta?
Resistance to viral infection
What is the role of IFN-gamma?
Macrophage activation
What is the role of IL-12?
IFN-gamma production by NK cells and T cells
What is the role of IL-15?
Proliferation of NK cells
What is the role of IL-10 and TGF-beta?
Control of inflammation
