Immunology Flashcards
1st degree immunology organs
Bone marrow- B cells
Thymus - T cells
2nd degree immunology organs
Spleen, lymph nodes, tonsils, Peter patches
What do 2nd degree immunology organs do?
Allow immune cells to interact with antigens
What are the functions of lymph nodes?
Non-specific filtration by macrophages, circulation of B and T cells, and immune response activation
3 parts of a lymph node
Follicle, medulla, paracortex
What does the follicle part of lymph node do? 1st degree vs 2nd degree
Site of B-cell localization and proliferation, in the outer cortex
1st degree follicles are dense and quiescent
2nd degree follicles have pale central germinal centres and are active
What does the medulla in the lymph node do?
Consists of medullary cords (closely packed lymphocytes and plasma cells) and medullary sinuses
What do the medullary sinuses do?
Communicate with efferent lymphatics and contain reticular cells and macrophages
What does the paracortex in lymph nodes do?
Contains T cells
Region of cortex between follicles and medulla
Contains high endothelial venules through which T and B cells enter from blood
When does paracortex enlarge?
Extreme cellular immune response (EBV or other viral infection)
Who doesn’t develop paracortex in lymph nodes
DiGeorge Syndrome
What drains into cervical/supracervicular nodes? Associated pathology?
Head and neck
URTI, mono, Kawasaki
What drains into mediastinal/hilar lymph nodes? Associated pathology?
Trachea, oesophagus
Lungs
Pulmonary TB, sarcoid, 1st degree lung cancer, granulomatous disease
Axillary lymph noes drain what? Pathology?
Upper limb, breast, skin above belly button
Mastitis
Metastasis (breast cancer!!)
Celiac, superr mesenteric, and inferior mesenteric drain? Pathology?
Foregut, midgut, handout
Mesenteric lymphadenitis, typhoid, UC, celiac
