Immunology Flashcards
Draw and name lymph node regions
Diagram of Spleen lymph region
Diagram Peyer’s Patch
High Endothelial Venules
Specialized blood vessels as point of enterance for lymphocytes to squeeze through into the lymph node
Follicle
B-cell area
Outer cortex of lymph node
Paracortical area
T cells diffusely distributed
adjacent to medullary cords (lower) and follicles (upper)
Flow in to center, DC and Macs, T-cell, B-cell
Germinal Center
Activated B-cells undergoing intense poliferation and differentiation into plasma cells
PALS
(spleen) Periarteriolar lymphoid sheath
Mainly T-cells
Surround primary arteriol like serpant
Marginal zone
(spleen) Surrrounds follical at intervals around PALS
Few T-cells, rich in macrophages, special resident noncirculating populatio of B-cells
Marginal Zone B Cells
MALT
GALT
Mucosal immune system
Gut-associated lymphoid tissue (includes tonsils, adenoids, appendix & Peyer’s patches)
Payer’s Patch
Antigen collected from lumin of GI (GALT), Upper resp. (NALT), Lower Airway (BALT) by M Cells (microfold)
Large centeral Follicle
Neutralization
Opsonization
Compliment Activation
Coating antigen(s) to destroy function
Coating of microbes targeting for phagocytosis/distruction
Coating - Fc region platform for complement binding
Th1
Th2
Th17
T(FH)
Induce Macrophages to increase killing power to distroy engulfed pathogens resistant to normal lysis conditions
Increases responses at mucosal surfaces (and parasitic infections) increase mucus, recrute eosinophils, IgE production
Promote responses with neutrophils (extracellular bacteria and fungal infections)
Resides in follicles, provide much of the help to B-cell activation to plasma cells
