Immunological Tolerance and Autoimmunity Flashcards
0
Q
What mutation is responsible for the breaking of central tolerance?
A
AIRE
1
Q
Peripheral and Central tolerance is/are induced by what?
A
Central- Induced in immature self-reactive lymphocytes in the generative lymphoid organs.
Peripheral- induced in mature self-reactive lymphocytes in peripheral sites.
2
Q
Describe some characteristics of CTLA-4.
A
CD28 family receptor, Inhibitory signal, provides signals that terminate immune response.
3
Q
What two signals are required for development and survival of T regulatory cells?
A
IL-2 and FoxP3.
4
Q
What are some immunosuppressive cytokines released by T regulatory cells?
A
IL-4, IL-10, TGF-beta.
5
Q
IL-4, IL-10, and TGF-beta have what affect of what molecules specifically?
A
down regulate CD40, CD80/86, IL-2.
Up regulate IL-10.
