Differentiation and Function of CD4+ cells Flashcards

0
Q

What are B7( CD80/CD86) proteins?

A

Co-stimulatory molecules expressed on professional APCs.

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1
Q

What three components are needed to activate a T cell?

A

1) TCR
2) CD4 or CD8
3) CD3 proteins

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2
Q

T cell proliferation is driven by what cytokine?

A

IL-2.

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3
Q

What is the commonality between Th1, Th2, Th17 cells?

A

All are CD4 positive helper cells.

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4
Q

What two cytokines are produced my dendritic cells and macrophages that lead to activation of transcription factors T-bet, STAT1, STAT4 in Th1 differentiation?

A

IL-12 produced by DCs and Macrophages and IFN-gamma produced by NK cells.

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5
Q

What are nontraditional T cells?

A

These T cells have gamma-delta TCRs and CD3. Abundant in the intestine, uterus, and tongue. Functions as first line of defense, regulatory cell, bridging between innate and adaptive responses.

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6
Q

What are Natural Killer T (NKT) cells?

A

Recognize self and foreign lipids and glycolipids. When activated, they will produce large quantities of IFN-gamma, IL-4, and GM-CSF. Deficiency of of NKT leads to autoimmunity, cancers, asthma.

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7
Q

What is the role of IL-5?

A

Activation of eosinophils.

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