Differentiation and Function of CD4+ cells

Question 0

What are B7( CD80/CD86) proteins?

Answer 0

Co-stimulatory molecules expressed on professional APCs.

Question 1

What three components are needed to activate a T cell?

Answer 1

1) TCR
2) CD4 or CD8
3) CD3 proteins

Question 2

T cell proliferation is driven by what cytokine?

Answer 2

IL-2.

Question 3

What is the commonality between Th1, Th2, Th17 cells?

Answer 3

All are CD4 positive helper cells.

Question 4

What two cytokines are produced my dendritic cells and macrophages that lead to activation of transcription factors T-bet, STAT1, STAT4 in Th1 differentiation?

Answer 4

IL-12 produced by DCs and Macrophages and IFN-gamma produced by NK cells.

Question 5

What are nontraditional T cells?

Answer 5

These T cells have gamma-delta TCRs and CD3. Abundant in the intestine, uterus, and tongue. Functions as first line of defense, regulatory cell, bridging between innate and adaptive responses.

Question 6

What are Natural Killer T (NKT) cells?

Answer 6

Recognize self and foreign lipids and glycolipids. When activated, they will produce large quantities of IFN-gamma, IL-4, and GM-CSF. Deficiency of of NKT leads to autoimmunity, cancers, asthma.

Question 7

What is the role of IL-5?

Answer 7

Activation of eosinophils.