B cell activation and Ab production (2)

Question 0

What are the bcl-2 family of proteins responsible for?

Answer 0

Anti-apoptotic signals.

Question 1

Isotype switching primarily occurs where and is driven by what cells?

Answer 1

Occurs in germinal centers and is driven by Tfh cells.

Question 2

Short-lived plasma cells are generated during what response?

Answer 2

T-independent response.

Question 3

Long-lived plasma cells are generated during what response?

Answer 3

T-dependent response. Generated by signals from the BCR and IL-21.

Question 4

What is a conjugate vaccine?

Answer 4

Created by attaching a poor antigen, covalently, to a carrier protein. The antigen must activate helper T cells in order for the vaccination to render an immune response.

Question 5

The FCgammaRIIB receptor activates what intracellular protein? What does this intracellular protein do? What occurs in mice with a KO of the FCgammaRIIB receptor?

Answer 5

Activates the SHIP protein. SHIP will convert PIP3-> PIP2 and thus block B cell receptor signaling. KO mice exhibit uncontrolled Ab production.