Immunoglobulins

Question 1

The gamma globulin constitute …………. % of the plasma protein

Answer 1

20-25 %

Question 2

The light and heavy chain of gammaglobulins weigh …………… and …………….. respectively

Answer 2

25,000 Da
50,000Da

Question 3

The hotspot on antibodies are regarded as ……………… or ………..

Answer 3

Hypervariability region
Complementarity determining region CDRs

Question 4

The hotspot in the variable region of the Light and heavy chains are ………….. and …………… respectively

Answer 4

3 and 4 respectively

Question 5

The hot spots show higher variability in their amino acid sequence and the part of the hotspot that binds the antigen is …………..

Answer 5

Paratope

Question 6

The immunoglobulin that have 3 constant region are ……….

Answer 6

G A D

Question 7

The immunoglobulin that have 3 constant region are ……….

Answer 7

G A D

Question 8

Which Ig is mostly produced in the body and constitutes the largest percentage of Ig in the body

Answer 8

IgG
70- 80%

Question 9

IgG has a half of ………

Answer 9

23 days

Question 10

There are ………… subclasses of IgG this occurs as a result of

Answer 10

4 subclasses
Variation in the amino acid configuration in the constant region of G heavy chain

Question 11

The IgG subclasses vary in 4 features
………….
…………
………….
………….

Answer 11

Amino acid configuration
Biological function
Length of the hinge region
No of disulfide bridges

Question 12

A subclass of IgG has the longest hinge region with ……….. interchain of disulfide

Answer 12

IgG 3
11 interchange of disulfide bonds