Gastrointestinal Function Test

Question 1

What is gastric ulcer ?
List the riak factors of GI ulcer

Answer 1

Loss or discontinuation of mucosa lining of the stomach

Blood group O
Damage to the mucosa lining
Helicobacter pylori

Question 2

What is the mechanism of action of helicobacter pylori

Answer 2

It secrets urease enzyme to protect its self from the gastric acid in the stomach turning it into a neutral medium

Question 3

Discuss the urea breath test

Answer 3

A patient is administered labelled C13 or C14 urea
If urease is present the urea is metabolised to ammonia and isotopically labelled CO2

Co2 is absorbed from the gut and expired and quantified
For diagnosis and monitoring

Question 4

List the three tests for helicobacter as a cause of gastric ulcer

Answer 4

Serological test
Urea breath test
Fecal antigen test

Question 5

What is serological test for hpylori

Answer 5

Uses ELISA test to test for antibodies
It could be false positive

Question 6

What is the zollinger -Ellison syndrome

Answer 6

Gastrinoma which results in excessive production of gastric acid.
It could be as a result of gastrin producing gland of the pancreas or the intenstine

Question 7

60 % of gastrinomas in zollinger- Ellison syndrome is …………….

Answer 7

Malignant
30% is part of MEN syndrome type 1

Question 8

ZE syndrome can lead to

Answer 8

Peptic ulcer
Steatorrhea

Question 9

What is the pathogenesis of steatorrhoea in ZE syndrome

Answer 9

The high H+ concentration is believed to inactivate pancreatic lipase enzyme leading to fat malabsorption